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黑线姬鼠实验动物化研究进展

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自新冠肺炎疫情以来,全球以动物为媒介的传染病不断发生,人们需要更多种类的实验动物作为研究样本.黑线姬鼠(Apodemus agrarius)是一种我国常见的农田害鼠,繁殖期短、适应能力强,在我国分布广泛,是影响我国农业生产的主要害鼠之一.另外,黑线姬鼠也是汉坦病毒(Hantavirus)、莱姆病伯氏疏螺旋体(Borrelia burgdorferi)和刚地弓形虫(Toxoplasma gondii)的天然携带者,是流行病学研究的重要调查样本,同时在构建疾病模型和探究病原体致病机制方面也更具优势,其实验动物化的研究情况应该受到重视.本文总结了黑线姬鼠分类及其分布、繁殖学研究、生理学研究、分子生物学研究、携带病原体概况,并对黑线姬鼠的繁殖研究、多组学应用、病原探究和发展前景进行展望,以期为黑线姬鼠后续实验动物资源开发提供帮助.
Recent Advances of Apodemus agrarius as Laboratory Animal
Since the COVID-19 outbreak,animal-mediated infectious diseases have been occurring around the world,and people need more species of experimental animals as research samples.Apodemus agrarius is a common farm rodent in China,with short breeding period and strong adaptability.It is widely distributed and is one of the main rodents affecting agricultural production in Chi-na.On the other hand,Apodemus agrarius is also a natural carrier of Hantavirus,Borrelia burgdorferi and Toxoplasma gondii,which is an important investigative sample in epidemiological studies,as well as being more advantageous in constructing disease models and probing the pathogenic mechanisms of pathogens,the research situation of its experimental animalization should be valued.The article summarized the classification and distribution,reproduction,physiology,molecular biology and the general situation of carrying pathogend.The reproduction studies,multi-omics applications,pathogen exploration and development prospects of the Apodemus a-grarius were discussed and outlooked,with a view to providing assistance for the subsequent development of experimental animal re-sources of the blackline guinea pig.

Apodemus agrariuslaboratory animalreproducecarrying pathogens

金志民、李强、鲁思含、孙悦、贾修歧

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牡丹江师范学院,黑龙江 牡丹江 157011

黑线姬鼠 实验动物 繁殖 携带病原

国家重点研发项目黑龙江省 2023年度省属高校基本科研业务费科研项目生物学学科卓越研究生培养模式改革创新项目生物学学科研究生导学思政团队牡丹江师范学院青年学术骨干项目牡丹江师范学院"揭榜挂帅"项目

2023YFF0724600MNUQN202305MSYZYXM2022004KCSZTD-2022012MNUQN202305kjcx2023-105mdjnu

2024

10.3969/j.issn.1006-6500.2024.05.005

天津农业科学
天津农业科学院信息研究所

天津农业科学

影响因子：0.705
ISSN：1006-6500
年,卷(期)：2024.30(5)