Exercise intervention as a key prevention and treatment strategy for type 2 diabetes mellitus(T2DM)has been generally accepted worldwide.Unfortunately,the"one-size-fits-all"interventions recommended by various physical activity guidelines do not result in the same benefits for all patients.The reasons are:first,the etiology,pathogenesis and clinical manifestations of T2DM are highly heterogeneous;second,the response of T2DM patients to exercise intervention is heterogeneous.These two heterogeneities affect the effectiveness of exercise intervention in T2DM,and to improve the effectiveness,precise typing and precise intervention for diabetes are required.Therefore,it is necessary to understand the principle and implementation process of precision motion intervention.In this review,we summarize the molecular genetic basis of T2DM,the molecular mechanism of exercise intervention,and the heterogeneity of patients'response to exercise,and comment on the current research progress in accurate typing,diagnosis,treatment,and monitoring of T2DM.,focusing on the causes and mechanisms of individual differences in T2DM patients'response to exercise,and put forward suggestions for using exercise prescription parameters as key variables in the precise treatment of T2DM.
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