脑类器官技术及在脑卒中治疗中的应用进展
Research progress of cerebral organoid technology and its application in stroke treatment
孙可心 1肖雨倩 1万俊 1陈淑颖 1陈丽敏 1王岩 2白艳杰2
作者信息
- 1. 河南中医药大学(邮编 450000)
- 2. 河南中医药大学第一附属医院
- 折叠
摘要
脑类器官是一种由胚胎干细胞(ESCs)或诱导多能干细胞(iPSCs)诱导产生的三维神经培养物,能够模拟人脑的结构和功能.随着脑类器官培养技术的不断优化,并与器官移植、基因编辑和类器官芯片等新兴技术相结合,产生了功能性血管结构和神经回路等复杂脑组织结构,为研究人类大脑发育和疾病提供了新方法、新思路.就脑类器官技术的最新进展进行综述,阐述了其在神经系统疾病中的应用,以及在脑卒中建模和移植治疗中的进展.
Abstract
Cerebral organoids are three-dimensional nerve cultures induced by embryonic stem cells(ESCs)or induced pluripotent stem cells(iPSCs)that mimic the structure and function of human brain.With the continuous optimization of cerebral organoid culture technology and the combination with emerging technologies such as organ transplantation,gene editing and organoids-on-chip,complex brain tissue structures such as functional vascular structures and neural circuits have been produced,which provides new methods and ideas for studying human brain development and diseases.This article reviews the latest advances in brain organoid technology,describes its application in neurological diseases and advances in stroke modeling and transplantation treatment.
关键词
类器官/移植/芯片分析技术/卒中/脑类器官Key words
organoids/transplantation/microchip analytical procedures/stroke/cerebral organoid引用本文复制引用
基金项目
河南省中医药科学研究专项重点课题(20-21ZY1009)
河南省中医药传承与创新人才工程(仲景工程)中医药学科拔尖人才项目(CZ0237-08)
河南省科技攻关计划(222102310529)
河南省卫生健康委国家中医临床研究基地科研专项(2022JDZX005)
河南省中医药拔尖人才培养专项(2022ZYBJ07)
出版年
2024
NETL
NSTL
万方数据