预防对比剂相关性急性肾损伤的研究进展
Research progress in the prevention of contrast-related acute kidney injury
樊汇 1马宇 2李曦铭3
作者信息
- 1. 天津医科大学(邮编 300070)
- 2. 天津大学胸科医院心血管内科
- 3. 天津大学胸科医院心血管内科;天津市心血管急危重症重点实验室
- 折叠
摘要
对比剂相关性急性肾损伤(CA-AKI)是在诊断或介入手术中使用对比剂所引起的一种严重并发症,目前已成为住院患者新发急性肾功能不全的主要原因之一.选择相对低毒的对比剂,减少对比剂暴露的时间和剂量对CA-AKI有一定的预防作用,他汀等药物以及术前术后的水化能够降低CA-AKI的风险,目前纳米药物已被证明在动物模型中获益.该文就当前CA-AKI的防治进行综述,为进一步深入研究新的干预措施奠定基础,并为临床治疗提供理论依据.
Abstract
Contrast-associated acute kidney injury(CA-AKI)is an important complication caused by the use of contrast medium(CM)in diagnostic or interventional surgery.At present,it has become one of the major causes of acute renal insufficiency in hospitalized patients.Choosing a relatively low toxic CM and reducing the exposure time and dose of CM can prevent CA-AKI occurrence to some extent.Drugs such as statins and postoperative hydration can reduce the risk of CA-AKI.In addition,nanomedicine has shown a benefit in animal models.This paper reviews the current prevention and treatment of CA-AKI to lay the foundation for further study of new interventions and provide a theoretical basis for clinical treatment.
关键词
造影剂/急性肾损伤/羟甲基戊二酰基CoA还原酶抑制剂/纳米粒子/补液疗法Key words
contrast media/acute kidney injury/hydroxymethylglutaryl-CoA reductase inhibitors/nanoparticles/fluid therapy引用本文复制引用
基金项目
天津市卫生健康科技项目青年人才项目(TJWJ2021QN056)
出版年
2024
NETL
NSTL
万方数据