RNA m6A甲基化在卒中后认知障碍中的研究进展
Research progress of RNA m6A methylation in post-stroke cognitive impairment
肖雨倩 1孙可心 1万俊 1陈淑颖 1陈丽敏 1王岩 1白艳杰2
作者信息
- 1. 河南中医药大学(邮编 450000)
- 2. 河南中医药大学第一附属医院
- 折叠
摘要
卒中后认知障碍(PSCI)主要表现为学习、记忆等方面的障碍.哺乳动物大脑中高度富集的RNA m6A甲基化修饰,参与神经胶质细胞介导的神经炎症.鉴于神经炎症是PSCI神经损伤以及空间和记忆能力下降的主要机制,推测RNA m6A甲基化修饰可调节脑卒中后神经胶质细胞炎症反应,进而改善PSCI.该文就RNA m6A甲基化修饰在PSCI发展中的作用及其调控神经胶质细胞介导的炎症的详细机制进行总结分析,为该领域的研究者提供参考.
Abstract
Post-stroke cognitive impairment(PSCI)is mainly manifested as learning and memory disorders.Highly enriched RNA m6A methylation modification in mammalian brain is involved in glial cell-mediated neuroinflammation.Given that neuroinflammation is the main mechanism for neural damage and spatial and memory impairment of PSCI,it is speculated that RNA m6A methylation modification can regulate the inflammatory response of glial cells after stroke to improve PSCI.This review summarizes and analyzes the role of RNA m6A methylation modification in the development of PSCI and analyzes its detailed mechanism of regulating glial cell-mediated inflammation,which will provide reference for researchers in this field.
关键词
卒中/认知障碍/炎症/小神经胶质细胞/星形细胞/m6A甲基化Key words
stroke/cognition disorders/inflammation/microglia/astrocytes/m6A methylation引用本文复制引用
基金项目
河南省中医药科学研究专项重点课题(20-21ZY1009)
河南省中医药传承与创新人才工程(仲景工程)中医药学科拔尖人才(CZ0237-08)
河南省科技攻关计划(222102310529)
河南省卫健委国家中医临床研究基地科研专项(2022JDZX005)
河南省中医药拔尖人才培养项目专项课题(2022ZYBJ07)
出版年
2024
NETL
NSTL
万方数据