Changes and clinical significance of white blood cell and platelet parameters of peripheral blood in Brucellosis patients
Objective To study changes of white blood cell(WBC)and platelet parameters in peripheral blood of Brucellosis patients so as to explore the clinical significance.Methods A total of 90 patients with confirmed Brucellosis were included,including 59 in the acute stage and 31 in the chronic stage.In addition,40 healthy people during the same period were selected as the healthy control group.Basic data such as clinical symptoms were collected.Total WBC count,lymphocyte count,neutrophil count,monocyte count,platelet count,mean platelet volume(MPV)and platelet distribution width(PDW)in peripheral blood were detected by automatic blood analyzer.The counts of CD3+T,CD4+T and CD8+T cells in peripheral blood were detected by flow cytometry.Neutrophil-lymphocyte ratio(NLR)and platelet/lymphocyte ratio(PLR)of patients were calculated.Changes of each cell parameter were analyzed and the clinical diagnostic value of each parameter for Brucellosis were analyzed.Results The proportion of arthralgia and spondylitis were higher in the chronic stage group than those in the acute stage group(P＜0.05).Compared with the healthy control group,the total number of WBC,neutrophil count,platelet count and NLR were decreased in the acute stage group,and MPV and PDW were decreased in the chronic stage group,and CD3+T cell count and monocyte count were increased(P＜0.05).White blood count,lymphocyte count,CD3+T cell count,and CD8+T cell count were lower in patients with acute Brucellosis with arthritic symptoms than those of patients without arthritis,while PLR was increased(P＜0.05).Receiver operating characteristic(ROC)curve analysis showed that the area under the curve of neutrophil count and NLR level for acute Brucellosis was 0.780 and 0.717,respectively,while the area under the ROC curve of CD3+T cell count for chronic Brucellosis was 0.748.In acute stage patients,the area under ROC curve of CD3+T,CD8+T cell count and PLR level for the diagnosis of arthritis was 0.779,0.768 and 0.722,respectively.Conclusion The indexes of WBC and platelet of peripheral blood in patients with acute and chronic human Brucellosis are changed abnormally,which has a certain reference value in diagnosis of human Brucellosis and arthritis in acute Brucellosis patients.
Brucellosisleukocyte countplatelet countarthritisarea under curve
万方数据
维普
