Correlation between serum miR-34a and miR-182 levels before PCI and postoperative contrast-induced nephropathy occurrence in elderly patients with acute coronary syndrome
Correlation between serum miR-34a and miR-182 levels before PCI and postoperative contrast-induced nephropathy occurrence in elderly patients with acute coronary syndrome
Objective To investigate the relationship between serum microRNA(miR)-34a and miR-182 levels before percutaneous coronary intervention(PCI)and postoperative contrast-induced nephropathy(CIN)occurrence in elderly patients with acute coronary syndrome(ACS).Methods A total of 146 elderly patients with ACS who underwent PCI were included.Clinical data of ACS patients were collected.The indexes of preoperative blood lipid and renal function were detected by automatic biochemical analyzer.Serum levels of miR-34a and miR-182 were determined by real time fluorescence quantitative PCR.Patients were divided into the CIN group(20 cases)and non-CIN group(126 cases)according to whether CIN occurred after PCI.Clinical data,preoperative blood lipids,renal function indexes,serum miR-34a,miR-182,postoperative serum creatinine(Scr)and glomerular filtration rate(eGFR)were compared between the CIN group and the non-CIN group.The correlation of preoperative serum miR-34a,miR-182,postoperative Scr,and eGFR in elderly patients with ACS were analyzed,and factors affecting the occurrence of CIN in elderly patients with ACS after PCI were also analyzed.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of preoperative serum miR-34a and miR-182 levels for occurrence of CIN in elderly patients with ACS after PCI.Results Preoperative serum miR-34a and miR-182 levels and postoperative Scr levels were higher in the CIN group than those in the non-CIN group,while postoperative eGFR level was lower than those in the non-CIN group(P＜0.05).Preoperative serum miR-34a and miR-182 were positively correlated with postoperative Scr,and negatively correlated with postoperative eGFR in elderly patients with ACS(P＜0.05).Preoperative serum miR-34a was positively correlated with miR-182(P＜0.05).The increase of serum miR-34a and miR-182 levels before surgery were an independent risk factor for occurrence of CIN in elderly patients with ACS after PCI(P＜0.05).The area under curve(AUC)of preoperative serum miR-34a,miR-182 and their combination in predicting postoperative occurrence of CIN in elderly ACS patients after PCI were 0.881,0.888,and 0.964,respectively.The AUC predicted by the two combined was higher than that predicted by each separately(P＜0.05).Conclusion The increased serum levels of miR-34a and miR-182 before surgery are risk factors for occurrence of CIN in elderly patients with ACS after PCI,and the combination of the two can effectively predict the occurrence of CIN.
维普
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