5-hydroxytryptamine(5-HT)is an important neurotransmitter in brain-gut axis pathway,and its secretion is closely related to intestinal flora,intestinal immunity and intestinal motility.Abnormal metabolic pathway of 5-HT is involved in the occurrence and development of gastrointestinal diseases,such as irritable bowel syndrome,inflammatory bowel disease,chronic constipation and functional dyspepsia.This article reviews the mechanism of 5-HT in different gastrointestinal diseases in order to explore new ideas for clinical treatment.
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