Diabetic cardiomyopathy(DCM)is one of the most serious cardiovascular complications in diabetic patients,and it is also the main cause of increased mortality in diabetic patients,which has become a major global public health problem.As an important intracellular regulatory protein in body,sirtuin 1(SIRT1)plays an important role in many biological processes,including reducing oxidative stress in cardiomyocytes,maintaining Ca2+ homeostasis in myocardial mitochondria,reducing myocardial endoplasmic reticulum stress,improving myocardial mitochondrial dysfunction,and inhibiting the activation of renin-angiotensin-aldosterone system.SIRT1 may be a potential therapeutic target for DCM.Further research targeting SIRT1 can provide a new theoretical basis for the clinical treatment of DCM.This article reviews the specific role of SIRT1 in the pathogenesis and treatment strategies of DCM.
关键词
糖尿病/糖尿病心肌病/抗衰老酶1/氧化性应激/线粒体/内质网应激/肾素-血管紧张素-醛固酮系统
Key words
diabetes mellitus/diabetic cardiomyopathies/sirtuin 1/oxidative stress/mitochondria/endoplasmic reticulum stress/renin-angiotensin-aldosterone system
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