The role and research progress of microglia in sepsis related encephalopathy
Sepsis associated encephalopathy(SAE)is a common complication in patients with sepsis.It is characterized by brain dysfunction,and a considerable proportion of patients have long-term cognitive impairment.The central nervous system is one of earliest regions affected by peripheral inflammation caused by sepsis.As resident immune cells of central nervous system,microglia can coordinate inflammatory responses in brain and play an important role in the innate and adaptive immune responses of brain.Therefore,it plays a crucial role in the occurrence and development of SAE.In this paper,the functional phenotypes of microglia and their role in SAE are reviewed to explore the potential value of microglia in the prevention and treatment of SAE.
sepsismicrogliasepsis related encephalopathysynapsesneuroinflammation
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