结缔组织病相关间质性肺病:从发病机制研究到"双达标"治疗策略
Connective tissue disease-associated interstitial lung disease:from pathogenesis to"dual-target"treatment strategies
李梦涛 1王迁1
作者信息
- 1. 中国医学科学院北京协和医院风湿免疫科,国家皮肤与免疫疾病临床医学研究中心(邮编 100730)
- 折叠
摘要
结缔组织病(CTD)是一类多器官系统受累的异质性疾病,间质性肺病(ILD)是多种CTD的严重并发症.不同CTD-ILD在发病机制、临床表现、治疗等方面存在较大异质性.基于遗传学、病理生理与免疫学、蛋白质组学、微生物组学进行相关基础及临床研究来探究CTD-ILD发病机制并提出"双达标"治疗策略.影像学技术及血清生物标志物研究的进展同时助力"双达标"治疗策略的实施,早期控制CTD活动与肺部炎症、延缓肺纤维化有利于改善CTD-ILD患者生存期与生活质量.
Abstract
Connective tissue diseases(CTD)are a spectrum of heterogeneous diseases with multiple organ involvements.Interstitial lung diseases(ILD)are serious complications of CTD.There is great heterogeneity in pathogenesis,clinical manifestations,and treatment of different CTD-ILD.Previous basic and clinical studies have explored the pathogenesis of CTD-ILD,and the"dual-target"treatment strategy has therefore emerged.The implementation of the"dual-target"treatment strategy helps to control CTD activity and lung inflammation in the early stage,prevent the progression of pulmonary fibrosis,and thus improve patient survival and quality of life.
关键词
结缔组织疾病/肺疾病,间质性/诊断/治疗/发病机制Key words
connective tissue diseases/lung diseases,interstitial/diagnosis/therapy/pathogenesis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据