皮肌炎自身抗体在间质性肺病中的研究进展
Research progress of dermatomyositis-related autoantibodies in interstitial lung disease
罗宴冉 1史晓飞 2韩磊 2张贝 2文路遥1
作者信息
- 1. 河南科技大学临床医学院(邮编 471003);河南科技大学第一附属医院风湿免疫科
- 2. 河南科技大学第一附属医院风湿免疫科
- 折叠
摘要
肌炎抗体分为肌炎特异性自身抗体(MSA)和肌炎相关性自身抗体(MAA).不同肌炎抗体在间质性肺病(ILD)中的作用机制、临床特点及预后等方面存在异质性.在MSA中,抗黑色素瘤分化相关基因5(MDA5)抗体和抗氨酰tRNA合成酶(ARS)抗体与ILD的发生高度相关.抗MDA5抗体阳性皮肌炎(DM)患者ILD的发生率高,进展迅速,预后较差.抗ARS抗体阳性DM患者ILD的病程缓慢,对治疗反应较好,但易复发.在MAA中,抗Ro52抗体通常与MSA抗体共存,临床表现与共存抗体关系密切.就肌炎自身抗体在ILD中的研究进展进行综述.
Abstract
Myositis antibodies are divided into myositis-specific autoantibodies(MSA)and myositis-associated autoantibodies(MAA).There are heterogeneity in the mechanism,clinical features and prognosis of interstitial lung disease(ILD)in the different myositis antibodies.In MSA,anti-melanoma differentiation-related gene 5(MDA5)antibody and anti-aminoacyl synthetase(ARS)antibody are highly correlated with the occurrence of ILD.Patients with MDA5+DM-ILD usually have a rapidly progressive and poor prognosis.The progress of ILD in ARS+DM patients was slow,and the response to treatment is good,but it is easy to relapse.In MAA,anti-Ro52 antibodies often coexist with MSA antibodies,and clinical manifestation is closely related to coexisting antibodies.This review has summarized roles of myositis antibodies in ILD.
关键词
皮肌炎/间质性肺病/自身抗体/临床特点/预后Key words
dermatomyositis/interstitial lung disease/antoantibody/clinical features/prognosis引用本文复制引用
基金项目
河南省医学科技攻关计划省部共建重点项目(SBGJ202002098)
出版年
2024
NETL
NSTL
万方数据