TGF-β信号通路在骨髓增生异常综合征中作用机制的研究进展
Research progress on the mechanism of the TGF-β signaling pathway in myelodysplastic syndrome
刘青青 1李宜蔷 1石玉士 1陆海颂 2程纬民2
作者信息
- 1. 广西中医药大学研究生学院(邮编 530001)
- 2. 广西中医药大学第一附属医院血液内科
- 折叠
摘要
骨髓增生异常综合征(MDS)是一种细胞遗传学与分子遗传学高度异质性的恶性克隆性疾病,且进展为急性髓系白血病(AML)的风险极高.转化生长因子-β(TGF-β)与MDS的发病密切相关,是免疫稳态及免疫耐受的关键执行者,可抑制免疫系统许多组成部分的扩张和功能.TGF-β信号通路能调控微环境中的造血细胞及免疫细胞,抑制其发挥正常生物学功能,从而加快MDS的疾病进展.就近年来TGF-β信号通路对MDS红细胞、T淋巴细胞、自然杀伤细细胞、巨噬细胞的调控作用进行综述,以期为MDS的发病机制及治疗提供新的视角.
Abstract
Myelodysplastic syndrome(MDS)is a malignant clonal disease with high heterogeneity in cytogenetics and molecular genetics,and the risk of progression to acute myeloid leukemia(AML)is extremely high.Transforming growth factor-β(TGF-β)is closely related to the pathogenesis of MDS.It is a key executor of immune homeostasis and immune tolerance,and can inhibit the expansion and function of many components of immune system.TGF-β signaling pathway can regulate hematopoietic cells and immune cells in microenvironment,inhibit their normal biological functions,and thus accelerate the progression of MDS.This study reviews regulatory effects of TGF-β signaling pathway on MDS blood cells,T lymphocytes,natural killer cells and macrophages in recent years,and provides a new perspective for the pathogenesis and treatment of MDS.
关键词
骨髓增生异常综合征/转化生长因子β/信号传导/免疫细胞/作用机制Key words
myelodysplastic syndromes/transforming growth factor beta/signal transduction/immune cells/mechanism of action引用本文复制引用
基金项目
广西中医药管理局资助项目(GZZC2019058)
出版年
2024
NETL
NSTL
万方数据