Radiation-induced heart disease(RIHD)is a cardiotoxic event secondary to radiotherapy for thoracic tumors,and has become another unfavorable factor affecting the health of cancer patients in addition to cancer cytotoxicity.Signal transduction plays an important role in cellular information exchange.RIHD can induce dysregulation of signaling pathways and hinder the normal function of pathways,thus causing myocardial tissue to undergo lesions such as apoptosis,oxidative stress and fibrosis.Now,we review the relevant pathways that are dysregulated in the development of RIHD,as well as the regulatory effects of drug intervention on these pathways,in order to provide a reference basis for the prevention and treatment of RIHD.
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