葡萄糖依赖性促胰岛素多肽与多囊卵巢综合征相关性的研究进展
Advances in the study of the correlation between incretin hormone GIP and polycystic ovary syndrome
范哲华 1刘建荣2
作者信息
- 1. 山西医科大学第五临床医学院(邮编 030000)
- 2. 山西省人民医院生殖医学科
- 折叠
摘要
多囊卵巢综合征(PCOS)是育龄妇女常见的生殖和内分泌疾病之一,机制未明,但胰岛素抵抗、高雄激素血症、肥胖是其重要的病理生理基础.葡萄糖依赖性促胰岛素多肽(GIP)是一种参与调控胰岛素分泌的胃肠激素,与胰岛素抵抗、高雄激素血症、肥胖等PCOS的特征性改变具有相关性,可能通过影响下丘脑-垂体-卵巢轴的功能促进PCOS的发生与发展,提示GIP与PCOS相关.就GIP与PCOS相关性的研究现状进行综述.
Abstract
Polycystic ovary syndrome(PCOS)is one of the most common reproductive and endocrine disorders in women of childbearing age,and the pathogenesis is unknown.Insulin resistance,hyperandrogenism and obesity are important pathophysiological basis.Glucose-dependent insulinotropic peptide(GIP)is a gastrointestinal hormone involved in the regulation of insulin secretion.Literature studies have shown that GIP is correlated with insulin resistance,hyperandrogenism,obesity and other characteristic changes of PCOS,and it may contribute to the onset and progression of PCOS by affecting the function of hypothalamic-pituitary-ovarian axis,suggesting that GIP is associated with PCOS.This paper reviews the research progress of the correlation between GIP and PCOS.
关键词
多囊卵巢综合征/肥胖症/胰岛素抵抗/葡萄糖依赖性促胰岛素多肽/高雄激素血症/下丘脑-垂体-卵巢轴Key words
polycystic ovary syndrome/obesity/insulin resistance/glucose-dependent insulinotropic polypeptide/hyperandrogenism/hypothalamic-pituitary-ovarian axis引用本文复制引用
基金项目
国家自然科学基金资助项目(81973864)
中央引导地方科技发展资金项目(YDZJSX2022A069)
出版年
2024
NETL
NSTL
万方数据