小胶质细胞极化在神经病理性疼痛中作用研究进展
Research progress on the role of microglia polarization in neuropathic pain
陈晶晶 1农章嵩 2谭良源 1杨培培 2梁英业 2唐宏亮 3王开龙2
作者信息
- 1. 广西中医药大学研究生院(邮编 530000)
- 2. 广西中医药大学第一临床医学院康复医学科
- 3. 广西中医药大学附属防城港医院
- 折叠
摘要
神经病理性疼痛(NPP)是一种反复且难以治愈的疼痛综合征,小胶质细胞极化与其有密切联系.小胶质细胞极化后可形成M1促炎型与M2抗炎型,M1型与M2型小胶质细胞通过调控炎症反应参与NPP.M1促炎型通过促炎因子和有害物质的释放在NPP中起到伤害作用;而M2抗炎型与之相反,通过分泌抗炎因子起到保护作用.就小胶质细胞极化对NPP作用的研究进展进行综述.
Abstract
Neuropathic pain(NPP)is a recurrent and intractable pain syndrome,and microglial polarization is closely related to it.Recent studies have shown that after cell polarization,M1 pro-inflammatory and M2 anti-inflammatory types could be formed,and M1 and M2 microglial cells are involved in NPP through the modulation of inflammatory responses.The two types of microglial cells have different roles in NPP,just like a double-edged sword.M1 pro-inflammatory type plays an injurious role in NPP through the release of pro-inflammatory factors and noxious substances,whereas M2 anti-inflammatory type plays a protective role by secreting anti-inflammatory factors.In this article,the role of microglia polarization on NPP are reviewed.
关键词
小神经胶质细胞/炎症/极化/神经病理性疼痛Key words
microglia/inflammat ion/polarization/neuropathic pain引用本文复制引用
基金项目
国家自然科学基金资助项目(82060902)
广西自然科学基金资助项目(2020GXNSFBA297107)
出版年
2024
NETL
NSTL
万方数据