ASIC1a介导类风湿关节炎软骨细胞损伤机制的研究进展
Research progress on the mechanism of ASIC1a-mediated chondrocyte injury in rheumatoid arthritis
钟玉梅 1周海燕 2张敏1
作者信息
- 1. 成都市第一人民医院/成都中医药大学附属中西医结合医院(邮编 610041)
- 2. 成都中医药大学针灸推拿学院
- 折叠
摘要
类风湿关节炎(RA)是临床难治性自身免疫性疾病,骨破坏是RA中晚期的主要病理特征.酸敏感离子通道1a(ASIC1a)是细胞外H+激活的阳离子通道家族的一员,可将细胞外微环境的低pH信号传递至细胞内,激活下游信号通路,诱导一系列的病理变化.ASIC1a在RA发病中具有关键的作用,可促进关节炎症、滑膜增生、骨及关节软骨的破坏,在RA病理过程中具有重要意义.就ASIC1a的分子特性进行概述,并重点关注其改善RA软骨损伤的可能机制,为治疗RA提供新的思路.
Abstract
Rheumatoid arthritis(RA)is a clinically refractory autoimmune disease.The destruction of bone and articular cartilage is a key pathological feature in the middle and late stages of RA.Acid-sensing ion channel 1a(ASIC1a)is a member of extracellular H+activated cation channel family,which can transmit low pH signal from extracellular microenvironment into cells,activate downstream pathways and induce a series of pathological changes.New evidence shows that ASIC1a plays a key role in the pathogenesis of RA,promoting joint inflammation,synovial hyperplasia and the destruction of bone and articular cartilage,which is of great significance in the pathological process of disease.In this paper,the molecular characteristics of ASIC1a are briefly reviewed,and the possible mechanism of ASIC1a to improve cartilage injury of RA is emphasized,so as to provide new ideas for the treatment of RA.
关键词
关节炎,类风湿/软骨细胞/酸敏感离子通道/细胞凋亡/细胞外酸化Key words
arthritis,rheumatoid/chondrocytes/acid sensing ion channels/apoptosis/extracellular acidification引用本文复制引用
基金项目
四川省自然科学基金青年项目(2023NSFSC1823)
四川中医药文化协同发展研究中心一般项目(2022XT73)
国家自然科学基金面上项目(81973959)
出版年
2024
NETL
NSTL
万方数据