The relationship between EOS,D-D and NLR in peripheral blood and pulmonary ventilation in patients with AECOPD
Objective To investigate changes of peripheral blood eosinophils(EOS),D-dimer(D-D)and neutrophil/lymphocyte ratio(NLR)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and their relationship with pulmonary ventilation function.Methods Sixty-five AECOPD patients(the observation group)and 65 COPD patients(the control group)were selected respectively and included in this study.Basic data were collected in the two groups of patients,and laboratory indexes were examined.EOS and D-D levels were determined,and NLR was calculated.The lung function indexes including the first second expiratory volume with exertion(FEV1),the first second expiratory volume with exertion as a percentage of expiratory lung capacity with exertion(FEV1/FVC),and blood gas indexes of arterial blood partial pressure of oxygen[p(O2)]and arterial blood partial pressure of carbon dioxide[p(CO2)]were detected.Multifactorial Logistic regression was used to analyze the influencing factors of AECOPD.The nomogram model of AECOPD was established and verified by R4.2.3.Results Compared with the control group,levels of EOS,D-D and NLR were elevated,and FEV1 and FEV1/FVC levels were reduced in the observation group(P＜0.05).Multifactorial Logistic regression analysis showed that elevated EOS,D-D and NLR,and reduced FEV1/FVC and FEV1 were independent risk factors for patients with AECOPD(P＜0.05).The area under the receiver operating characteristic(ROC)curve of AECOPD nomogram model was 0.817(95%CI:0.784-0.904),and the Hosmer-Lemeshow test showed goodness of fit of the model(χ2=4.320,P＞0.05).EOS,D-D and NLR were positively correlated with FEV1 and FEV1/FVC(P＜0.05).Conclusion The elevated levels of EOS,D-D and NLR are risk factors that affect pulmonary ventilation in AECOPD patients,which can be used as an important indicator to evaluate pulmonary ventilation function.
万方数据
维普
