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新型烧烫伤药膏促进小鼠烧烫伤创面愈合的表观形态分析

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本试验采用分析小鼠创面愈合表观形态的方法,以新疆南疆当地特色土著药用植物为试材研制新型烧烫伤药膏,并分析该药膏对小鼠背部浅Ⅱ度和深Ⅱ度烧烫伤创面愈合的影响.试验建立了 3 组小鼠烧烫伤模型:空白对照组、新型烧烫伤药膏组和疗效对照组(市售某烧伤膏),分别对比分析 3 组小鼠烧烫伤创面愈合过程中的创口直径、创面愈合率及愈合时间的差异.结果表明,与空白对照组相比,新型烧烫伤药膏组和疗效对照组的创面愈合时间明显缩短,具有统计学意义(P<0.05);新型烧烫伤药膏对小鼠深Ⅱ度、浅Ⅱ度的烧烫伤具有一定的治疗效果,能够明显缩短结痂时间和愈合时间,且治疗深Ⅱ度烧烫伤的效果明显优于疗效对照组.因此,采用新疆南疆当地特色野生药用植物研制的新型烧烫伤药膏对小鼠烧烫伤具有明显的治疗效果,可以明显缩短烧烫伤创面的愈合时间、结痂时间.
Analysis of the apparent morphology of the new burn ointment in promoting the healing of burn wound in mice
A new type of burn ointment was developed using local indigenous medicinal plants in Southern Xinjiang as test materials in this experiment.And the apparent morphology analysis of wound healing in mice was conducted to evaluate the effect of this ointment on the healing of superficial and deep second degree burn wounds on the back of mice.Three groups of mice burn models were established:blank control group,new burn ointment group,and therapeutic control group.The differences in wound diameter,wound healing rate,and healing time during the healing process of burn wounds in the three groups of mice were compared and analyzed.The results showed that compared with the blank control group,the wound healing time of the new burn ointment group and the therapeutic control group was significantly shortened,with statistical significance(P<0.05).The new burn ointment has a certain therapeutic effect on deep and superficial second degree burns in mice,which can significantly shorten the scab formation time and healing time.And its effect of treating deep second degree burns is significantly better than that of a commercially available burn ointment group.Therefore,the new burn ointment developed by the local wild medicinal plants in Southern Xinjiang exhibited obvious therapeutic effect on burn wound in mice,and can obviously shorten the healing time and scab formation time.

mouseburn and scaldointmentwound healingmedicinal plant

周航震、张金佩、杨蕾、刘佳鑫、徐孟龙、管浩丞、李树伟

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塔里木大学生命科学与技术学院/塔里木盆地生物资源保护利用兵团重点实验室-省部共建国家重点实验室培育基地,新疆 阿拉尔 843300

小鼠 烧烫伤 药膏 创面愈合 药用植物

2024

塔里木大学学报
塔里木大学

塔里木大学学报

CHSSCD
影响因子:0.313
ISSN:1009-0568
年,卷(期):2024.36(4)