摘要
目的 建立健康儿童直流电刺激诱发(galvanic vestibular stimulation,GVS)的颈肌前庭诱发肌源性电位(cervical vestibular evoked myogenic potential,cVEMP)和眼肌前庭诱发肌源性电位(ocular vestibular evoked myogenic potential,oVEMP)的检测方法,并确定正常范围.方法 对健康儿童20例(3～14岁)和健康成人24例(18～30岁)分别进行GVS-cVEMP和GVS-oVEMP检测,儿童组直流电刺激强度不超过3 mA,成人组最大刺激强度5 mA,记录两组GVS-cVEMP和GVS-oVEMP的引出率和特点,并进行不同刺激强度下的疼痛评分.结果 GVS-cVEMP和GVS-oVEMP在儿童组和成人组的引出率均为100.0％.儿童组GVS-cVEMP的p1潜伏期、n1潜伏期和p1-n1波间期分别为10.46±1.84 ms、16.98±2.12 ms和6.52±1.42 ms,n1潜伏期和p1-n1波间期较成人组明显缩短(P＜0.05).儿童组GVS-oVEMP的n1潜伏期、p1潜伏期和p1-n1波间期分别为8.87± 1.40 ms、12.25±1.80 ms和3.39±1.07 ms,与成人组无明显差异.儿童组GVS-cVEMP和GVS-oVEMP的阈值均明显低于成人组(P＜0.01),但振幅和振幅不对称比无明显差异.本文健康儿童检测结果可作为其正常范围.随着电流刺激强度的增加,受试者的疼痛评分增高,其对应的GVS-cVEMP和GVS-oVEMP的引出率也增加.结论 采取3 mA刺激强度和适宜的记录方法,可在3岁以上儿童及青少年人群中进行GVS-cVEMP和GVS-oVEMP检测并引出波形,并得到了其正常范围,儿童GVS-cVEMP潜伏期略短于成人,进行评估时,建议选取同年龄段健康儿童进行比较.
Abstract
Objective To establish the methods of galvanic vestibular stimulation-vestibular evoked myogenic potentials(GVS-VEMPs)in healthy children and to obtain the normal value of GVS-cVEMP and GVS-oVEMP in these children in China.Methods Twenty(3～14 years)healthy children and 24 healthy adults(18～30 years)were enrolled for conventional examinations of GVS-cVEMP and GVS-oVEMP.Using the galvanic stimulation in-tensity under 3 mA/1 ms for children and 5 mA/1 ms for adults.The characteristics of elicitation and parameter re-sults of GVS-cVEMP and GVS-oVEMP in children and adults,as well as the pain scores and the elicitation of differ-ent stimulus intensities in the two age groups were recorded.Results The elicitation of GVS-cVEMP and GVS-oVEMP were both 100.0％in children and adult groups.The p1 latency,n1 latency and p1-n1 interval latency of GVS-cVEMP were 10.46±1.84 ms,16.98±2.12 ms and 6.52±1.42 ms respectively in children group,the n1 la-tency and p1-n1 interval latency were significantly shorter than the adult group(P＜0.05).The n1 latency,p1 la-tency and p1-n1 interval latency of GVS-oVEMP were 8.87±1.40 ms,12.25±1.80 ms and 3.39±1.07 ms re-spectively in children group with no significant difference between the two groups.The thresholds of GVS-cVEMP and GVS-oVEMP in children group were significantly lower than adult group(P＜0.01),but no differences were found in adult group regarding on the amplitude and interaural amplitude asymmetry ratio.In addition,with the in-crease of the intensity of galvanic stimulation,the correlation between pain scores and the elicitation rates of GVS-cVEMP and GVS-oVEMP also increased.Conclusion Using appropriate stimulus intensity and recording methods,GVS-cVEMP and GVS-oVEMP could be successfully assessed and detected in healthy children over 3 years old and adolescents.The latency of GVS-cVEMP in children is slightly shorter than that in adults,therefore we recommend selecting the matched age group for assessment in the children group.
基金项目
国家自然科学基金项目(81970891)
国家自然科学基金项目(82171137)
陕西省国际科技合作重点项目(2017KW-048)
陕西省国际合作重点研发计划项目(2020KWZ-019)
维普
万方数据