HCN通道在听觉传导通路中的作用研究进展
Research Progress on the Role of HCN Channels in Auditory Pathway
葛鑫颖 1周沫 1刘锦峰 1戴金升 1原晶晶 2刘梦婷 1张娟 1王宁宇1
作者信息
- 1. 首都医科大学附属北京朝阳医院耳鼻咽喉头颈外科(北京 100020)
- 2. 北京中医药大学东直门医院耳鼻咽喉科
- 折叠
摘要
超极化激活环核苷酸门控阳离子通(hyperpolarization-activated cyclic nucleotide-gated channel,HCN channel)广泛表达于中枢和周围神经系统,通过其介导的超极化激活阳离子电流(hyperpolarization-activated cation current,Ih)调节神经元的静息膜电位和兴奋性来影响听觉的精确加工和传导,对时间信息的精确分析起着至关重要的作用.因此,本文通过对HCN通道结构和分布以及电生理作用进行综述,进一步探讨HCN通道在正常及单侧聋或双侧聋情况下听觉传导通路中的作用及机制.
Abstract
Hyperpolarization-activated cyclic nucleotide-gated(HCN)channels are widely expressed in the central and peripheral nervous systems.They can generate hyperpolarization-activated current(Ih)that regulates the resting membrane potential and excitability of neurons.Furthermore,it can affect the precise processing and con-duction of hearing,which plays a crucial role in the accurate analysis of temporal information.Therefore,through the review of HCN channel structure and distribution,as well as electrophysiological effects,the role and mecha-nism of HCN channels in the auditory pathways of the normal and unilateral or bilateral deafness patients will be fur-ther investigated.
关键词
HCN通道/超极化激活阳离子电流/听觉传导/单侧听觉剥夺/声源定位Key words
Hyperpolarization-activated cyclic nucleotide-gated(HCN)channel/Hyperpolarization-activa-ted current(Ih)/Auditory conduction/Unilateral auditory deprivation/Sound localization引用本文复制引用
基金项目
国家重点研发计划(2020YFC2005202)
国家自然科学基金(81900934)
国家自然科学基金(81770993)
首发专项重点项目(2020-1-2032)
出版年
2024
NETL
NSTL
万方数据