Objective To investigate the characteristics of mismatch negativity(MMN)in patients with total deafness of sudden hearing loss with different prognosis,and to assess whether MMN is associated with the progno-sis of sudden hearing loss patients.Methods Fifty-one cases of sudden hearing loss with unilateral total deafness were selected for pure tone audiometry(PTA)and auditory MMN examination before treatment,and 26 subjects with mornal hearing were included as the normal group.After routine treatment for 10 days according to the guide-lines for sudden hearing loss,PT A examination was performed to determine their recovery status,and they were di-vided into ineffective group and effective group according to prognosis.The characteristics of MMN latency and am-plitude in the effective group and the ineffective group were observed and compared with the normal control group.Results The MMN waveform was elicited normally in 51 patients with sudden hearing loss and 26 cases in the nor-mal group,of which 29 were in effective group and 22 were in ineffective group.There were significant statistical differences in MMN latency between the patients group and the normal group(P＜0.05).Anova showed no signifi-cant difference in MMN latency between the invalid group and the effective group(P＞0.05),and there was no sig-nificant difference in amplitude among the three groups(P＞0.05).Conclusion The MMN latency of sudden hear-ing loss patients was signifanty shortened.There were no differences in MMN latency and amplitude between the in-effective group and the effective group.
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