首页|生蒲黄汤合泻心汤加减在糖尿病视网膜病变治疗中的效果分析

生蒲黄汤合泻心汤加减在糖尿病视网膜病变治疗中的效果分析

Effect of Shengpuhuang Decoction Combined with Xiexin Decoction in the Treatment of Diabetic Retinopathy

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目的 探讨生蒲黄汤合泻心汤加减在糖尿病视网膜病变(Diabetes Retinopathy,DR)患者中的治疗效果.方法 选取2021年5月—2023年4月诸城市人民医院眼科收治的96例DR患者为研究对象,以信封法分为两组,各48例.对照组采用卵磷脂络合碘治疗,观察组联合生蒲黄汤合泻心汤加减干预,比较两组血流动力学(视网膜)、视力指标及药物安全性.结果 两组干预2周后视网膜血流动力学得到改善;观察组视网膜中央静脉回流速度及阻力指数低于对照组,差异有统计学意义(P均<0.05);收缩期峰值流速、舒张末期流速、平均血流速度高于对照组,差异有统计学意义(P均<0.05);两组干预2周后视力水平得到改善;观察组最佳矫正视力、视网膜厚度、视网膜电图振荡电位及眼底出血面积低于对照组,差异有统计学意义(P均<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论 生蒲黄汤合泻心汤加减有助于改善DR患者血流动力学及视力水平,且药物安全性较高.
Objective To investigate the therapeutic effect of Shengpuhuang Decoction combined with Xiexin Decoc-tion in patients with diabetic retinopathy(DR).Methods A total of 96 DR Patients admitted to the Department of Oph-thalmology of Zhucheng People's Hospital from May 2021 to April 2023 were selected as the research objects.Accord-ing to the envelope method,they were divided into the observation group and the control group,with 48 cases in each group.The control group was treated with leciin iodine,and the observation group was treated with Shengpuhuang de-coction and Xiexin decoction.The hemodynamics(retina),visual acuity indexes and drug safety were compared be-tween the two groups.Results The retinal hemodynamics of the two groups were improved after 2 weeks of interven-tion.The central retinal vein and resistance index in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).The peak systolic velocity,end-diastolic volume and mean velocity in the observation group were higher than those in the control group,and the differences were statisti-cally significant(all P<0.05).The visual acuity of the two groups was improved after 2 weeks of intervention.The best Corrected Visual Acuity,retinal thickness,oscillatorypotentials and fundus hemorrhage area in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Shengpuhuang Decoction and Xiexin Decoction can improve the hemodynamics and visual acuity of DR Patients,and the drug safety is high,worthy of popularization and application.

Shengpuhuang Decoction and Xiexin DecoctionDiabetic retinopathyRetinal hemodynamicsVisual acuity indexDrug safety

王萍、隋亚楠、贺庆强

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诸城市人民医院眼科,山东诸城 262200

生蒲黄汤合泻心汤 糖尿病视网膜病变 视网膜血流动力学 视力指标 药物安全性

2024

糖尿病新世界
中国病理生理学会

糖尿病新世界

影响因子:0.461
ISSN:1672-4062
年,卷(期):2024.27(1)
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