Objective To investigate the effects of dapagliflozin combined with metformin treatment on blood glucose and islet sensitivity in patients with type 2 diabetes mellitus(T2MD).Methods 70 T2MD patients admitted to Long-yan First Hospital Affiliated to Fujian Medical University from July 2020 to June 2022 were selected and divided into the combination group(n=35)and the monotherapy group(n=35)by random number table method.Metformin was given to the monotherapy group and dapagliflozin combined with metformin was given to the combination group to com-pare the efficacy of the two groups.Results After treatment,the levels of glucose,glycasylated hemoglobin,2-hour plasma glucose,homeostatic model assessment-insulin resistance,malondialdehyde,and advanced oxidation protein product were lower in the combination group than those in the monotherapy group,and the levels of homeostasis model assessment-insulin sensitivity,homeostasis model assessment-β,total-antoxidant capability,superoxide dis-mutase,and catalase were higher than those in the monotherapy group,and the differences were statistically signifi-cant(all P<0.05).Conclusion Dapagliflozin combined with metformin treatment can effectively regulate glucose me-tabolism in T2MD patients,enhance islet sensitivity,reduce insulin resistance status,control blood glucose levels,and significantly improve the oxidation-antioxidant balance of the body.
关键词
2型糖尿病/达格列净/二甲双胍/血糖/胰岛敏感性
Key words
Type 2 diabetes mellitus/Dapagliflozin/Metformin/Blood glucose/Islet sensitivity
维普
万方数据