Objective To investigate the effects of lipoic acid injection combined with pancreatic kininogenase enteric-coated tablets on the clinical efficacy,quality of survival and safety of patients with type 2 diabetic peripheral neuropathy(DPN).Methods 60 DPN patients admitted to Suixi County Hospital of Traditional Chinese Medicine from February 2021 to April 2022 were selected as the study objects.They were divided into two groups with 30 cases in each group by random number table method.The control group received conventional treatment,and the observation group was treated with lipoic acid injection and pancreatic kininogenase enteric-coated tablets on the basis of control group.Neuropathy score,neuroelectrophysiological index,quality of life score,safety index and incidence of adverse reactions were compared between the two groups.Results After treatment,the neuropathy score of observation group(6.2±0.9)points was lower than that of control group(7.6±1.1)points,and the difference was statistically significant(t= 5.438,P<0.05).Neuroelectrophysiological indexes,quality of survival scores and safety indexes of the observation group were better than those of the control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Li-poic acid injection combined with pancreatic kininogenase enteric-coated tablets has good clinical efficacy in DPN pa-tients,which can improve nerve function,improve nerve electrophysiological indexes,improve life quality,and have high safety.
关键词
硫辛酸注射液/胰激肽原酶肠溶片/2型糖尿病周围神经病变/临床疗效
Key words
Lipoic acid injection/Pancreatic kininogenase enteric-coated tablets/Peripheral neuropathy in type 2 diabetes mellitus/Clinical efficacy
维普
万方数据