Objective To explore the effects of Xuebijing combined with insulin pump on oxidative stress and blood glucose control in patients with diabetic ketoacidosis(DKA).Methods A total of eighty patients with DKA admitted to Linyi Third People's Hospital from January 2020 to December 2022 were selected and divided into control and obser-vation groups according to random number table method,with forty patients in each group.Control group was given in-sulin glargine injection,observation group was given Xuebijing injection on the basis of control group.The indexes of oxidative stress,blood glucose,acidosis,improvement time of clinical symptoms and occurrence of adverse reactions were compared between the two groups.Results After treatment,malondialdehyde(MDA)in observation group was lower than that in control group,superoxide dismutase(SOD)and tricarboxylic acid cycle(TAC)were higher than those in control group,and the differences were statistically significant(all P<0.05).After treatment,2-hour postpran-dial blood glucose(2 hPG),fasting blood glucose(FPG)and glycosylated hemoglobin(HbA1c)in observation group were lower than those in control group,and the differences were statistically significant(all P<0.05).After treatment,blood lactic acid(Lac)and serum β-hydroxybutyric acid(β-HB)in observation group were lower than those in con-trol group,carbon dioxide binding power(CO2CP)and serum thiamine concentration were higher than those in control group,and the differences were statistically significant(all P<0.05).The time of blood glucose standard,urine ketone body negative time and pH recovery time in observation group were better than those in control group,and the differ-ences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reac-tions between the two groups(P>0.05).Conclusion Xuebijing combined with insulin pump can improve the oxidative stress index of DKA patients,reduce blood glucose,improve acidosis,reduce the improvement time of clinical symp-toms,and reduce the incidence of adverse reactions.
维普
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