Objective To explore the effects of different insulin administration methods on blood glucose level,clini-cal indexes and hypoglycemia in patients with diabetic ketoacidosis admitted to emergency department.Methods A to-tal of 106 diabetic ketoacidosis patients from the emergency department of Guangqian Hospital of Quanzhou city from October 2022 to September 2023 were selected as the study objects.The patients were divided into control group and study group according to simplified randomization method,with 53 cases in each group.The control group received continuous intravenous infusion of low-dose insulin,and the study group received subcutaneous infusion of insulin pump.The blood glucose levels and clinical indicators of the two groups were compared,and the blood glucose levels included fasting plasma glucose(FPG),2 h postprandial plasma glucose(2 hPG)and glycosylated hemoglobin(HbAlc).Results After treatment,the levels of FPG,2 hPG and HbAlc in the study group were lower than those in the control group,the differences were statistically significant(all P<0.05).Urine ketone body recovery time,blood ketone body recovery time,blood glucose compliance time,pH value recovery time of the study group were shorter than those of the control group,the differences were statistically significant(all P<0.05),and the insulin dosage of the study group was less than that of the control group,the difference was statistically significant(P<0.05).Conclusion Insulin pump subcutaneous infusion is effective for patients with emergency diabetic ketoacidosis,and it can effectively im-prove the blood glucose level of patients,shorten the recovery time of urine ketone bodies and blood ketone bodies,and accelerate blood glucose compliance and pH recovery.In addition,insulin pump treatment can also reduce the amount of insulin.