Clinical Value of Urinary Protein and Urinary Microalbumin in Early Dia-betic Nephropathy
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维普
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目的 探讨尿蛋白及尿微量白蛋白联合检测对糖尿病早期肾病的临床检验价值.方法 选取2022年1-12月三明市第二医院就诊收治的26例糖尿病早期肾损伤(Early Diabetic Nephropathy,EDN)患者纳入EDN组,选择同期就诊治疗的26例单纯糖尿病(Diabetes Mellitus,DM)患者纳入DM组,同时将体检中心26例体检健康者纳入对照组.比较各组患者尿蛋白、尿微量白蛋白(Urinary Microalbumin,UMA)水平,分析单一指标与联合指标检测的灵敏度、特异度、准确度水平,绘制受试者工作(Receiver Operating Characteristic Curve,ROC)曲线并评估曲线下面积(Area Under the Curve,AUC).结果 EDN组患者尿蛋白及UMA水平均高于DM组与健康组,DM组尿蛋白及UMA水平高于健康组,差异有统计学意义(P均<0.05);联合检测组检测灵敏度(92.31%)高于单一检测组,差异有统计学意义(P均<0.05),联合检测组AUC值0.902(95%CI 0.837～0.966)高于单一检测组,差异有统计学意义(P<0.05).结论 尿蛋白及尿微量白蛋白联合检测可提高对早期糖尿病肾病的临床检验灵敏度及准确度,在临床检验工作中具有较高的价值,有助于糖尿病患者早期肾损伤的评估及治疗.
Objective To explore the clinical value of urinary protein and urinary microalbumin combined detection in early diabetic nephropathy.Methods A total of 26 patients with Early Diabetic Nephropathy(EDN)admitted to Sanming Second Hospital from January to December 2022 were selected to be included in the EDN group,26 patients with simple Diabetes Mellitus(DM)who received treatment during the same period were selected to be included in the DM group,and 26 healthy patients in the physical examination center were included in the control group.The levels of urinary protein and Urinary Microalbumin(UMA)were compared among all groups,and the sensitivity,specificity and accuracy of single index and combined index were analyzed.The Receiver Operating Characteristic Curve(ROC)curve and the Area Under the Curve(AUC)were plotted.Results The levels of urine protein and UMA in EDN group were higher than those in DM group and healthy group,the levels of urine protein and UMA in DM group were higher than those in healthy group,the differences were statistically significant(all P<0.05).The detection sensitivity(92.31%)of the combined detection group was higher than those of the single detection group,the difference was sta-tistically significant(P<0.05),and the AUC value of the combined detection group was 0.902(95%CI 0.837-0.966),which was higher than that of the single detection group,the difference was statistically significant(P<0.05).Conclusion The combined detection of urinary protein and urinary microalbumin can improve the sensitivity and ac-curacy of clinical test for early diabetic nephropathy,and has high value in clinical test work,which is helpful to the assessment and treatment of early diabetic kidney injury.
维普
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