Objective To evaluate the role and clinical significance of plasma D-dimer level detection in patients with type 2 diabetic nephropathy.Methods All the medical records of 120 patients with type 2 diabetic nephropathy admitted to Xiamen Hospital of Traditional Chinese Medicine from January 2021 to January 2022 were retrospectively analyzed.According to the urinary albumin ejection rate(UACR),the patients were divided into normal albuminuria group(n=40,UACR<20 μg/min),microalbuminuria group(n=40,UACR>200 μg/min)and large urinary protein group(n=40,UACR>200 μg/min),with 40 cases in each group.40 healthy subjects in the same period were selected as the control group,and all of them were examined by plasma D-dimer level to analyze the effect and clinical significance.Results The level of D-dimer in the large urinary protein group was higher than that in the microalbuminuria group,the normal albuminuria group and the control group,and comparison of D-dimer levels in 4 groups the differences were statistically significant(all P<0.05).Plasma D-dimer was positively correlated with albuminuria level in type 2 diabetic nephropathy patients(r=0.253).Conclusion The higher the level of proteinuria in type 2 diabetic nephropa-thy patients,the higher the level of plasma D-dimer,which can be used as an important reference index to detect the disease progression in diabetic nephropathy patients.
维普
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