Objective To study the therapeutic effect of liraglutide combined with metformin in diabetes.Methods From July 2019 to July 2021,a total of 90 diabetic patients admitted to the Department of Endocrinology of Zichuan District Hospital of Zibo were selected as the research objects.According to the random number table method,they were divided into the study group and the control group,with 45 cases in each group.The study group was treated with liraglutide combined with metformin,and the control group was treated with metformin.The adverse reactions,glyco-sylated hemoglobin(HbA1c),fasting plasma glucose(FPG),2-hour postprandial plasma glucose(2 hPG),tumor necro-sis factor-α(TNF-α),serum amyloid A(SAA),interleukin-6(IL-6)and body mass index(BMI)were observed and compared between the two groups.Results After treatment,the levels of HbA1c,FPG and 2 hPG in the study group were all lower than those in the control group,and the differences were statistically significant(all P<0.05).After treat-ment,the levels of TNF-α,SAA and IL-6 in the study group were all significantly lower than those in the control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the total in-cidence of adverse reactions between the study group and the control group(P>0.05).After treatment,the BMI level of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Liraglutide combined with metformin can reduce body weight of patients,relieve inflammation,improve pancreatic islet function,and reduce blood glucose in patients with diabetes.It is safe and has significant therapeutic effect.
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