Objective To explore the clinical effect of metformin combined with insulin aspart in the treatment of preg-nant women with gestational diabetes,and the effects of the blood glucose control and pregnancy outcomes of pregnant women.Methods The clinical date of 80 pregnant women with gestational diabetes admitted to Qinghai Provincial Women and Children's Hospital from April 2021 to April 2023 were retrospectively analyzed.According to different treatment they were divided into control group(n=40,treated with insulin aspart)and the study group(n=40,treated with metformin combined with insulin aspart).Compared blood glucose levels,time for blood glucose to return to nor-mal,insulin dosage,the level of inflammatory factors,and maternal and infant outcomes between the two groups.Results The fasting blood glucose,2-hour postprandial blood glucose,and glycosylated hemoglobin in the study group were all lower than those in the control group,and the differences were statistically significant(all P<0.05).The time for fasting blood glucose and 2-hour postprandial blood glucose to return to normal,and the amount of insulin in the study group were less than those in the control group,and the differences were statistically significant(all P<0.05).In-terleukin-6 and tumor necrosis factor-α in the study group were lower than those in the control group,and the differ-ences were statistically significant(both P<0.05).The incidence of adverse pregnancy outcomes in the study group was lower than that in the control group and the difference was statistically significant(P<0.05).Conclusion In the treatment of gestational diabetes,taking metformin and injecting insulin aspart has a significant effect,which can ef-fectively control blood glucose and improve pregnancy outcomes.
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