Objective To explore the improvement of microcirculation and infection symptoms in patients with dia-betic foot infection after infrared irradiation.Methods A total of one hundred patients with diabetic foot infection who received treatment in the Department of Hospital-acquired Infection Control of Quanzhou Hospital for Infectious Dis-ease Prevention and Control from August 2021 to January 2023 were selected as the study objects.They were divided into study group(n=50,conventional treatment combined with infrared irradiation)and control group(n=50,conven-tional treatment)according to random number table method.The clinical treatment effect,changes in hemorheology in-dexes,changes in ulcer size before and after treatment,and differences in infection control effect between the two groups were compared.Results Ther total effective rate in the study group was 98.00%(49/50),which was significantly higher than 86.00%(43/50)in the control group,the difference was statistically significant(P<0.05).There was no sta-tistically significant difference in whole blood viscosity,plasma viscosity,fibrinogen level and ulcer surface between the two groups before treatment(P>0.05).After treatment,the above indexes in the study group were significantly lower than those in the control group,the differences were statistically significant(all P<0.05).There was no statisti-cally significant difference in the detection rate of purulent secretions and the positive rate of pathogenic bacteria be-tween the two groups before treatment(P>0.05).After treatment,the detection rate of purulent secretion and the posi-tive rate of pathogenic bacteria in the study group were significantly lower than those in the control group,the differ-ence was statistically significant(both P<0.05).Conclusion The effect of infrared irradiation on patients with diabetic foot infection is certain,which can significantly improve the local microcirculation state and infection state of patients,reduce the ulcer surface of patients.