Objective To investigate the effects of liraglutide on adipocytokines,blood glucose and renal function in patients with diabetic kidney disease(DKD).Methods A total of 120 DKD patients admitted to Dongshan County Hos-pital of Fujian Province from January 2020 to December 2022 were selected as the study objects,and were divided into the reference group and the observation group according to the random number table method,with 60 cases in each group.All patients were given oral treatment of glipazone and irbesartan,the reference group was given oral treat-ment of pioglitazone on the basis of it,and the observation group was changed from oral pioglitazone to subcutaneous injection of liraglutide.Both groups received continuous treatment for 12 weeks.The adipocytokines,blood glucose and renal function indexes of two groups were compared before and after 12 weeks of treatment.Results Adipocyto-kines after treatment was higher than that before treatment,lactone was lower than that before treatment,and adipocy-tokines after treatment in observation group was higher than that in reference group,lactone level was lower than that in reference group,the differences were statistically significant(all P<0.05).The fasting plasma glucose and 2 h post-prandial blood glucose levels after treatment were lower than before treatment,and the observation group was lower than the reference group,the differences were statistically significant(all P<0.05).The levels of cystatin,β2 micro-globulin and α1 microglobulin in both groups after treatment were lower than before treatment,and the observation group was lower than the reference group,the differences were statistically significant(all P<0.05).Conclusion Lira-glutide can improve adipocytokines and blood glucose control in DKD patients,and provide good protection for renal function.
LiraglutideDiabetic kidney diseaseAdipocytokinesBlood glucoseRenal function
NETL
NSTL
维普
万方数据
