首页|牙周基础治疗联合替硝唑胶囊在糖尿病性牙周炎患者牙龈指数改善中的研究

牙周基础治疗联合替硝唑胶囊在糖尿病性牙周炎患者牙龈指数改善中的研究

Study on Improvement of Gum Index in Patients with Diabetic Periodonti-tis by Periodontal Basic Therapy Combined with Tinidazole Capsule

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目的 探究牙周基础治疗联合替硝唑胶囊在糖尿病性牙周炎患者改善牙龈指数中的效果.方法 随机抽取德化县医院牙科于2022年10月—2023年9月收治的68例糖尿病性牙周炎患者作为研究对象,并采用随机数表法划分为对照组和观察组,每组34例,对照组治疗中采用常规的牙周基础治疗,观察组在采用牙周基础治疗的基础上联合使用替硝唑胶囊进行治疗.观察两组患者治疗前后血清炎性因子指标变化、牙龈指数、菌斑指数及龈沟出血指数的变化以及临床疗效差异.结果 两组患者治疗前血清炎性因子水平比较,差异无统计学意义(P>0.05);治疗后两组患者的促炎因子-α(Tumor Necrosis Factor-α,TNF-α)、白细胞介素-6(Interleukin-6,IL-6)、超敏C-反应蛋白(Hypersensitive C-Reactive Protein,hs-CRP)水平均降低,且观察组指标水平较对照组更低,差异有统计学意义(P均<0.05);治疗前两组牙龈、菌斑及龈沟出血指数比较,差异无统计学意义(P>0.05);治疗干预后两组明显改善,且观察组改善程度优于对照组,差异有统计学意义(P<0.05);观察组临床总治疗有效率明显高于对照组,差异有统计学意义(P<0.05).结论 在糖尿病性牙周炎患者的治疗中,采用牙周基础治疗联合替硝唑胶囊的治疗方式能够更好控制牙周炎症,改善患者牙龈指数,菌斑指数,出血指数,让治疗总有效率更高,效果极佳.
Objective To explore the effect of periodontal basic treatment combined with tinidazole capsule in improv-ing the gum index of diabetic periodontitis patients.Methods A total of 68 patients with diabetic periodontitis admit-ted to Dehua County Hospital from October 2022 to September 2023 were randomly selected as the study objects,and divided into control group and observation group with random number table method,with 34 cases in each group.The control group was treated with conventional periodontal basic treatment,and the observation group was treated with ti-nidazole capsule on the basis of periodontal basic treatment.The changes of serum inflammatory factors,gun index,plaque index and gingival sulcus bleeding index before and after treatment and the difference of clinical efficacy were compared between the two groups of pateints.Results There was no statistically significant difference in serum inflam-matory factor levels between the two groups of patients before treatment(P>0.05),and the tumor necrosis factor-a(TNF-α),interleukin-6(IL-6)and hypersensitive-C-reactive-protein(hs-CRP)levels of the two groups were de-creased after treatment,and the indexes of the observation group were lower than those of the control group,and the differences were statistically significant(all P<0.05).Gun,plaque and gingival sulcus bleeding index were higher be-fore treatment and there was no statistically significant difference between the two groups(P>0.05).After treatment,the two groups improved significantly,and the improvement of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).The total therapeutic effectiveness of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of diabetic periodontitis,the combination of periodontal basic treatment and tinidazole capsule can better control periodontal inflammation,improve patients'gum index,plaque index and bleeding index,so that the total effective rate of treatment is higher and the effect is excellent.

Periodontal basic treatmentTinidazole capsuleDiabetic periodontitisGun index

林齐东、蔡晓蕾、甘丹凤

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德化县医院口腔科,福建泉州 362500

牙周基础治疗 替硝唑胶囊 糖尿病性牙周炎 牙龈指数

2024

糖尿病新世界
中国病理生理学会

糖尿病新世界

影响因子:0.461
ISSN:1672-4062
年,卷(期):2024.27(3)
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