糖化血红蛋白和尿微量白蛋白检测在早期糖尿病肾病中的临床意义
Clinical Significance of Glycosylated Hemoglobin and Urinary Microalbu-min Detection in Early Diabetic Nephropathy
蔡燕丽 1杨传玉1
作者信息
- 1. 尤溪县妇幼保健院检验科,福建三明 365100
- 折叠
摘要
目的 分析糖化血红蛋白(Glycosylated Hemoglobin A1c,HbA1c)、尿微量白蛋白(Urinary Microalbumin,mALB)检测在早期糖尿病肾病(Diabetic Kidney Disease,DKD)中的临床应用价值.方法 选取2021年10月—2022年10月尤溪县妇幼保健院收治的30例早期DKD患者作为观察1组,30例单纯糖尿病患者作为观察2组,20例参与健康体检的健康人群作为对照组.再依据临床与病理过程及2012年改善全球肾脏病预后组织发布的慢性肾病评估与管理临床实践指南提出的病因-肾小球滤过率-白蛋白尿分期将观察1组30例早期DKD患者分为1期组、2期组,各15例.对比各组HbA1c、mALB差异.结果 观察1组HbA1c、mALB高于观察2组及对照组,差异有统计学意义(P均<0.05);2期组患者HbA1c、mALB高于1期组,差异有统计学意义(P均<0.05).结论 HbA1c、mALB在早期DKD的诊疗过程中具有极高的应用价值,可作为诊断辅助指标,同时通过检测可判断DKD严重程度,HbA1c、mALB水平与早期糖尿病严重程度成正比.
Abstract
Objective To analyze the clinical value of glycosylated hemoglobin A1c(HbA1c)and urinary microalbu-min(mALB)detection in the early diabetic nephropathy(DKD).Methods Thirty patients with early DKD treated in Youxi County Maternal and Child Health Hospital from October 2021 to October 2022 were selected as observation group 1,30 patients with simple diabetes mellitus as observation group 2,and 20 healthy people participating in physical examination as control group.Then,according to the clinical and pathological process and the etiology-glo-merular filtration rate-albuminuria stage proposed in the Clinical Practice Guidelines for the Evaluation and Manage-ment of Chronic Kidney Disease published by Improving the Global Prognosis of Kidney Disease in 2012,30 patients with early DKD in the observation group 1 were divided into stage 1 group and stage 2 group,with 15 cases each.The differences of HbA1c and mALB among all groups were compared.Results HbA1c and mALB in observation group 1 were higher than those in observation group 2 and control group,and the differences were statistically significant(both P<0.05).HbA1c and mALB in stage 2 group were significantly higher than those in stage 1 group,the differences were statistically significant(both P<0.05).Conclusion HbA1c and mALB have high application value in the diagno-sis and treatment of early DKD,and can be used as auxiliary diagnostic indicators.At the same time,the severity of DKD can be judged by detection.The level of HbA1c and mALB is proportional to the severity of early diabetes.
关键词
糖化血红蛋白/尿微量白蛋白/早期糖尿病肾病/临床意义Key words
Glycosylated hemoglobin/Urinary microalbumin/Early diabetic nephropathy/Clinical significance引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据