首页|尿白蛋白、免疫球蛋白G及β2微球蛋白对老年糖尿病肾病的诊断价值

尿白蛋白、免疫球蛋白G及β2微球蛋白对老年糖尿病肾病的诊断价值

Diagnostic Value of Urinary Albumin,Immunoglobulin G and β2 Micro-globulin in Elderly Diabetic Nephropathy

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目的 分析在老年糖尿病患者诊断中尿白蛋白、免疫球蛋白G及β2 微球蛋白临床检验的诊断价值.方法 选取2021年1月—2023年6月南靖县医院收治的单纯性老年糖尿病患者45例为单纯性老年糖尿病组,老年糖尿病肾病患者25例为老年糖尿病肾病组,并选取同期健康体检者70例为对照组,3组患者均接受尿白蛋白、免疫球蛋白G及β2微球蛋白临床检验,对检验结果进行比较,分析尿白蛋白、免疫球蛋白G及β2微球蛋白单项及联合检验方式对老年糖尿病肾病诊断的特异性、灵敏性及准确性.结果 单纯性老年糖尿病组和老年糖尿病肾病组尿白蛋白、免疫球蛋白G、β2微球蛋白水平均高于对照组,单纯糖尿病组上述指标水平均低于糖尿病肾病组,差异有统计学意义(P均<0.05);3种方式联合检验的敏感度为92.00%,高于β2微球蛋白的60.00%,差异有统计学意义(P<0.05).结论 将尿蛋白、免疫球蛋白G、β2微球蛋白运用到老年糖尿病诊断中可以有效判断患者是否存在糖尿病,具有较高准确性和敏感性,有利于提高糖尿病肾病诊断检出率,并评估患者病情严重程度,可作为重要辅助诊断指标.
Objective To analyze the diagnostic value of urinary albumin,immunoglobulin G and β2 microglobulin in the diagnosis of elderly patients with diabetes.Methods Forty-five elderly patients with simple diabetes admitted to Nanjing County Hospital from January 2021 to June 2023 were selected as the simple elderly diabetes group,twenty-five elderly patients with diabetic nephropathy admitted during the same period were selected as the elderly diabetic nephropathy group,and seventy healthy patients during the same period were selected as the control group.Urinary al-bumin,immunoglobulin G and β2 microglobulin were tested in groups.The test results of the two groups were com-pared and analyzed.The various detection indexes were compared and analyzed.The specificity,sensitivity and accu-racy of urine albumin,immunoglobulin G and β2 microglobulin single and combined test methods for the diagnosis of diabetic nephropathy in the elderly were analyzed.Results The levels of urinary albumin,immunoglobulin G and β2 microglobulin in simple diabetic group and diabetic nephropathy group were higher than those in control group,the above indexes in simple diabetes group were lower than those in diabetic nephropathy group,and the differences were statistically significant(all P<0.05).The sensitivity of the three methods combined test was 92.00%,higher than that of β2 microglobulin 60.00%,and the difference was statistically significant(P<0.05).Conclusion The application of urinary protein,immunoglobulin G and β2 microglobulin in the diagnosis of diabetes in elderly patients can effec-tively determine whether patients have diabetes,with high accuracy and sensitivity,which is conducive to improving the diagnosis and detection rate of diabetic nephropathy,and evaluating the severity of patients'disease,and can be an important auxiliary diagnostic indicator.

Clinical testElderly diabetes mellitusUrinary albuminImmunoglobulin Gβ2 microglobulinDiagnos-tic value

吴祥云、王崇胜、许银海

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南靖县医院检验科,福建漳州 363000

临床检验 老年糖尿病 尿白蛋白 免疫球蛋白G β2微球蛋白 诊断价值

2024

糖尿病新世界
中国病理生理学会

糖尿病新世界

影响因子:0.461
ISSN:1672-4062
年,卷(期):2024.27(3)
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