Objective To explore the clinical efficacy and safety of Qiju Dihuang Decoction combined with Western medicine in the treatment of diabetic retinopathy.Methods 60 patients with diabetic retinopathy in Zhucheng People's Hospital from May 2021 to October 2023 were selected as the study objects and were divided into control group(30 cases)and study group(30 cases)by random number table method.The control group was given western medicine treatment,and the study group was supplemented with Qiju Dihuang Decoction.The clinical efficacy of the two groups was compared.Results The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,angiopoietin-1,vascular endothelial growth factor,plasma specific viscosity and fibrinogen indexes in the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in the in-cidence of adverse reactions between the two groups(P>0.05).Conclusion On the basis of conventional Western medicine treatment for diabetic retinopathy,Qiju Dihuang Decoction can improve the curative effect,control the neo-vascularization,improve the hemodynamics,and alleviate the pathological damage of retina.