Objective To observe the therapeutic effect of different types of sodium-dependent glucose transporters 2(SGLT2)inhibitors in patients with heart failure and type 2 diabetes and their influence on clinical prognosis.Methods 250 patients with heart failure combined with type 2 diabetes mellitus admitted to the Department of Inter-nal Medicine Section Two of Jiexi County People's Hospital from October 2022 to October 2023 were selected as the study objects.According to the use of SGLT2 inhibitors,the patients were divided into 5 groups:cagliaglitzin group,dagliaglitzin group,engliaglitzin group and etoglitzin group and control group(only received conventional treatment without SGLT2 inhibitor),with 50 cases in each group.The changes of glycosylated hemoglobin(HbA1c),fasting blood glucose,2 h postprandial blood glucose,left ventricular ejection fraction(LVEF)and brain natriuretic peptide(BNP)before and after treatment were compared in the 5 groups.Results There was no statistically significant differ-ence in HbA1c,fasting blood glucose,2 h postprandial blood glucose levels among the 5 groups before treatment(all P>0.05).After 2 months of treatment,HbA1c,fasting blood glucose,2 h postprandial blood glucose levels in all groups was significantly lower than those before treatment,and the HbA1c level in dagliaglitzin group was lower than that in other groups,the differences were statistically significant(all P<0.05).There were no statistically significant differences in LVEF and BNP levels among the 5 groups before treatment(both P>0.05).After 1 year of follow-up,LVEF in the 5 groups was significantly higher than before treatment,BNP was significantly lower than before treat-ment,LVEF in dagliaglitzin group was higher than that in other groups,and BNP was lower than that in other groups,the differences were statistically significant(all P<0.05).Conclusion Different types of SGLT2 inhibitors can play an ideal therapeutic effect in the face of heart failure patients with type 2 diabetes.Among them,the efficacy of daglia-glitzin is slightly better than that of cagliaglitzin,cagliaglitzin,and etoglitzin.
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