Effect of Insulin Glargine Combined with Acarbose on Blood Glucose Con-trol in Elderly Patients with Type 2 Diabetes
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目的 分析老年2型糖尿病实施甘精胰岛素+阿卡波糖治疗的效果.方法 选取2022年10月—2023年10月枣庄市皮肤病性病防治院收治的92例老年2型糖尿病患者作为研究对象,以奇偶数分组,分为单药组、联合组,各46例,单药组行甘精胰岛素治疗,联合组在单一组的基础上增加阿卡波糖治疗,比较两组血糖控制情况、胰岛功能、有效率、不良反应.结果 治疗前两组血糖指标对比,差异无统计学意义(P>0.05).治疗后联合组的血糖指标低于单药组,差异有统计学意义(P<0.05).治疗前两组胰岛β细胞指数(Homeostasis Model Assessment-β,HOMA-β)、胰岛素抵抗指数(Insulin Resistance Index,HOMA-IR)对比,差异无统计学意义(P均>0.05).治疗后联合组的HOMA-IR水平低于单药组,HOMA-β水平高于单药组,差异有统计学意义(P均<0.05).联合组治疗总有效率为97.83%,高于单药组的82.61%,差异有统计学意义(P<0.05).联合组的不良反应总发生率为8.70%,与单药组的4.35%对比,差异无统计学意义(P>0.05).结论 甘精胰岛素+阿卡波糖的方案控制血糖效果尤为显著,可恢复胰岛素功能,提升有效率,对老年2型糖尿病较适用.
Objective To analyze the effect of insulin glargine+acarbose in the treatment of elderly type 2 diabetes.Methods 92 cases of elderly type 2 diabetes mellitus patients admitted in Zaozhuang Dermatology and Venereal Dis-ease Prevention and Control Hospital from October 2022 to October 2023 were selected as the study object,which grouped by odd-even number,divided into monotherapy group and combined group,with 46 cases in each group.The monotherapy group carried out glycemic insulin treatment,and the combined group increased acarbose treatment based on the monotherapy group.The glycemic control situation,the function of insulin,the effective rate and the ad-verse reactions were compared between the two groups.Results Comparison of blood glucose indexes between the two groups before treatment,the difference were not statistically significant(P>0.05).After treatment,the blood glucose in-dexes of the combination group were lower than those of the monotherapy group,and the difference was statistically significant(P<0.05).Comparison of homeostasis model assessment-β(HOMA-β)and insulin resistance index(HOMA-IR)in the two groups before treatment,and the differences were not statistically significant(both P>0.05).Af-ter treatment,the level of HOMA-IR of the combination group was lower than that of the monotherapy group,and the level of HOMA-β was higher than that of the monotherapy group,and the differences were statistically significant(both P<0.05).The total effective rate of treatment in the combination group was 97.83%,higher than 82.61%in the monotherapy group,and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the combination group were 8.70%,compared with 4.35%in the monotherapy group,and the difference was not sta-tistically significant(P>0.05).Conclusion The regimen of insulin glargine + acarbose is particularly effective in con-trolling blood glucose,restoring insulin function,enhancing efficiency,and is more applicable to older adults with type 2 diabetes.
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