Objective To analyze the effect of adding semaglutide to metformin on blood glucose levels in the treat-ment of elderly patients with type 2 diabetes mellitus(T2DM).Methods A total of 96 elderly patients with T2DM ad-mitted to the Quanzhou First Hospital from January to October 2023 were selected as the research objects,and were divided into the reference group(n=48,application of metformin alone)and the observation group(n=48,combination of semaglutide with metformin on the basis of metformin)by coinage method,and the blood glucose level,the level of inflammatory factors,and the incidence of adverse reactions were compared between the two groups.Results Com-pared with before treatment,there was decrease in blood glucose levels in both groups after 90 days of treatment,and the observation group was lower than the control group,the differences were statistically significant(all P<0.05).Com-pared with before treatment,after 90 days of treatment,the levels of interleukin-10(IL-10)were higher,while levels of interleukin-6(IL-6)and interleukin-12(IL-12)decreased in both groups.The levels of IL-6 and IL-12 in the ob-servation group were lower than those in the control group,and IL-10 was higher than that in the control group,the differences were statistically significant(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).The total effective rate of treatment in the observation group(95.83%)was higher than that in the reference group,and the difference was statistically significant(χ2=5.031,P<0.05).Conclusion The addition of semaglutide to metformin in the treatment of elderly patients with T2DM disease can improves the patients'blood glucose level and inflammatory factor level,improves the clinical therapeutic effect,and has a high degree of safety.
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