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糖尿病视网膜病变的血液指标危险因素及临床应用价值

Blood Index Risk Factors and Clinical Application Value of Diabetic Reti-nopathy

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目的 探讨糖尿病视网膜病变的血液指标危险因素.方法 回顾性选取2013年9月—2017年9月北京市中国人民解放军总医院收治的3 000例确诊为2型糖尿病患者的临床资料.根据糖尿病患者是否并发视网膜病变分为两组,即糖尿病未并发视网膜病变(Non-diabetic Retinopathy,NDR)组和糖尿病视网膜病变(Diabetic Retinopathy,DR)组,各1 500例,比较两组糖尿病患者血液指标差异性的基础上,采用二元Logistic回归模型分析糖尿病视网膜病变血液指标危险因素.结果 NDR组与DR组血糖、血脂、肾功能、肝功能及其他血液相关指标比较,差异有统计学意义(P均<0.05).糖尿病患者的空腹血糖、血红蛋白、谷草转氨酶降低是DR的独立保护因素(P均<0.05).糖尿病患者的糖化血红蛋白、血尿素、血清尿素升高是DR的独立危险因素(P均<0.05).结论 在临床实践中将空腹血糖、血红蛋白、谷草转氨酶、糖化血红蛋白、血尿素、血清尿素作为快速识别和筛查糖尿病患者并发视网膜病变风险的血液指标,有针对性地对糖尿病视网膜病变风险进行早期干预,减少糖尿病视网膜病变的发生.
Objective To explore the risk factors of blood indexes in diabetes retinopathy.Methods 3 000 clinical data of patients diagnosed with type 2 diabetes who were admitted to the Chinese People's Liberation Army General Hospital in Beijing from September 2013 to September 2017 were retrospective selected.The diabetic patients were divided into two groups according to whether they had retinopathy or not.The diabetic patients with non-diabetic reti-nopathy(NDR)and diabetic retinopathy(DR)patients 1 500 cases each.Based on the difference of blood indexes be-tween the two groups of diabetic patients,binary Logistic regression model was used to analyze the risk factors of blood indexes of diabetic retinopathy.Results There were statistically significant differences in blood glucose,blood lipid,kidney function,liver function and other blood-related indexes between NDR group and DR group(all P<0.05).The decrease of fasting blood glucose,hemoglobin and glutamic oxalacetic transaminase in diabetic patients were in-dependent protective factors for DR(all P<0.05).The increase of glycosylated hemoglobin,blood urea and serum urea in diabetic patients were independent risk factors for DR(all P<0.05).Conclusion In clinical practice,fasting blood glucose,hemoglobin,glutamic oxaloacetic transaminase,glycosylated hemoglobin,blood urea,and serum urea are used as blood indicators to quickly identify and screen the risk of diabetes patients complicated with retinopathy,so as to carry out targeted early intervention on the risk of diabetes retinopathy and reduce the occurrence of diabetes retinopathy.

Diabetes retinopathyType 2 diabetesBlood indicatorsRisk factors

杨正凤、温振

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贵州医科大学(医药卫生管理学院),贵州贵阳 550025

博仁大学国际学院,泰国曼谷 10210

糖尿病视网膜病变 2型糖尿病 血液指标 危险因素

2024

糖尿病新世界
中国病理生理学会

糖尿病新世界

影响因子:0.461
ISSN:1672-4062
年,卷(期):2024.27(4)
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