Objective To explore the risk factors of blood indexes in diabetes retinopathy.Methods 3 000 clinical data of patients diagnosed with type 2 diabetes who were admitted to the Chinese People's Liberation Army General Hospital in Beijing from September 2013 to September 2017 were retrospective selected.The diabetic patients were divided into two groups according to whether they had retinopathy or not.The diabetic patients with non-diabetic reti-nopathy(NDR)and diabetic retinopathy(DR)patients 1 500 cases each.Based on the difference of blood indexes be-tween the two groups of diabetic patients,binary Logistic regression model was used to analyze the risk factors of blood indexes of diabetic retinopathy.Results There were statistically significant differences in blood glucose,blood lipid,kidney function,liver function and other blood-related indexes between NDR group and DR group(all P<0.05).The decrease of fasting blood glucose,hemoglobin and glutamic oxalacetic transaminase in diabetic patients were in-dependent protective factors for DR(all P<0.05).The increase of glycosylated hemoglobin,blood urea and serum urea in diabetic patients were independent risk factors for DR(all P<0.05).Conclusion In clinical practice,fasting blood glucose,hemoglobin,glutamic oxaloacetic transaminase,glycosylated hemoglobin,blood urea,and serum urea are used as blood indicators to quickly identify and screen the risk of diabetes patients complicated with retinopathy,so as to carry out targeted early intervention on the risk of diabetes retinopathy and reduce the occurrence of diabetes retinopathy.