摘要
目的 研究2型糖尿病肾病患者尿白蛋白肌酐比(Urinary Albumin Creatinine Ratio,UACR)和视网膜微循环各项参数的相关性.方法 选取2022年3-12月苏州大学附属第三医院及苏州大学附属常州老年病医院收治的95例2型糖尿病肾病患者为研究对象.根据UACR水平分为U1组(UACR<10 mg/g,28例,28眼)、U2组(UACR:10～30 mg/g,46例,46眼)、U3组(UACR:30～300 mg/g,21例,21眼).利用光学相干断层成像,测量3组患者黄斑中心凹区和旁中心凹区浅层毛细血管丛血流密度(Superficial Capillary Plexus Vessel Den-sity,SCP-VD)、深层毛细血管丛血流密度(Deep Capillary Plexus Vessel Density,DCP-VD)、中心凹无血管区(Foveal Avascular Zone,FAZ)面积与周长,观察指标差异,分析指标与UACR相关性.结果 3组患者中心凹区SCP-VD、旁中心凹区SCP-VD、中心凹区DCP-VD、旁中心凹区DCP-VD、FAZ面积比较,差异有统计学意义(P均<0.05);3组患者FAZ周长比较,差异无统计学意义(P>0.05);UACR与中心凹区SCP-VD、旁中心凹区SCP-VD、中心凹区DCP-VD、旁中心凹区DCP-VD负相关(r=-0.410、-0.689、-0.545、-0.627,P均<0.05),与FAZ面积正相关(r=0.463,P<0.05).结论 2型糖尿病患者UACR与中心凹区SCP-VD、旁中心凹区SCP-VD、中心凹区DCP-VD、旁中心凹区DCP-VD、FAZ面积存在相关性.OCTA视网膜微循环参数可作为糖尿病肾病损害程度的评估指标.
Abstract
Objective To study the correlation between urinary albumin creatinine ratio(UACR)and various param-eters of retinal microcirculation in patients with type 2 diabetes nephropathy.Methods Ninety-five patients with type 2 diabetic nephropathy admitted to the Third Affiliated Hospital of Soochow University and Changzhou Geriatric Hos-pital of Soochow University from March to December 2022 were selected as the study objects.According to UACR level,they were divided into U1 group(UACR<10 mg/g,28 cases,28 eyes),U2 group(UACR:10-30 mg/g,46 cases,46 eyes)and U3 group(UACR:30-300 mg/g,21 cases,21 eyes).Using optical coherence tomography,Superficial Capillary Plexus Vessel Density,superficial capillary plexus vessel density,superficial capillary plexus vessel density,superficial capillary plexus vessel density,Gold ascular Zone(SCP-VD),Deep Capillary Plexus Vessel Density(DCP-VD),and Foveal Avascular Zone(FAZ)area and perimeter,and differences in observational parameters,The correla-tion between the index and UACR was analyzed.Results The areas of foveal SCP-VD,parafoveal SCP-VD,foveal DCP-VD,parafoveal DCP-VD,and FAZ were negatively correlation among 3 groups(all P<0.05).There was posi-tively correlation in the circumference of FAZ among 3 groups(P>0.05).UACR was negatively correlated with foveal SCP-VD,parafoveal SCP-VD,foveal DCP-VD,parafoveal DCP-VD(r=-0.410,-0.689,-0.545,-0.627,all P<0.05),and positively correlated with FAZ area(r=0.463,P<0.05).Conclusion In type 2 diabetes mellitus,UACR was corre-lated with foveal SCP-VD,parafoveal SCP-VD,foveal DCP-VD,parafoveal DCP-VD,and FAZ area.Retinal micro-circulation parameters of OCTA can be used as an index to evaluate the damage degree of diabetic nephropathy.
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