Effects of Shenqi Jiangtang Granules Combined with Methylcobalamin In-jection on the Levels of MBP,BDNF,and NGF in Patients with Peripheral Neuropathy in Type 2 Diabetes Mellitus
Objective To investigate the effects of Shenqi Jiangtang granules combined with methylcobalamin injec-tion on the levels of human myelin basic protein(MBP),human brain-derived neurotrophic factor(BDNF),and nerve growth factor(NGF)in patients with peripheral neuropathy in type 2 diabetes mellitus.Methods 62 patients with type 2 diabetic peripheral neuropathy admitted to Xiamen Qianpu Hospital from May 2019 to December 2020 were se-lected as study objects and divided into the Western medicine group and the observation group by randomized numeri-cal table method,with 31 cases in each group.The Western medicine group was treated with intramuscular injection of methylcobalamin injection,and the observation group was treated with Shenqi Jiangtang granules on the basis of the Western medicine group.The clinical effects and drug safety of the two groups were compared,as well as the TCM evi-dence points,nerve conduction velocity and MBP,BDNF and NGF levels before and after treatment.Results The total effective rate of the observation group(96.77%)was higher than that of the western medicine group(74.19%),and the difference was statistically significant(χ2=6.369,P<0.05).After 3 months of treatment,all TCM evidence points of both groups were reduced significantly,and compared with the western medicine group,the observation group was lower,and the differences were statistically significant(all P<0.05).Nerve conduction velocity was elevated signifi-cantly in both groups after 3 months of treatment,and compared with the western medicine group,it was higher in the observation group,and the differences were statistically significant(all P<0.05).MBP level of the observation group was lower than that of the western drug group after 3 months of treatment,BDNF and NGF of the observation group were higher than that of the western drug group,and the differences were statistically significant(all P<0.05).The inci-dence rates of adverse reactions in the western medicine group and observation group were 6.45%and 9.68%,respec-tively,and the difference was not statistically significant(P>0.05).Conclusion The application of Shenqi Jiangtang granules combined with methylcobalamin injection in patients with type 2 diabetic peripheral neuropathy has signifi-cant therapeutic effect,which significantly reduces the patients'TCM evidence points and MBP levels,and enhances the nerve conduction velocity and the levels of BDNF,NGF.
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