Objective To analyze the risk factors of hypoglycemia in hemodialysis patients with diabetes mellitus(DM)combined with chromic renal failure(CRF).Methods A total of 82 patients of DM combined with CRF received hemodialysis admitted to Jinjiang Hospital from January 2021 to January 2023 were randomly selected as the study ob-jects,and they were divided into the occurrence group(n=27)and the non-occurrence group(n=55)according to the occurrence of hypoglycemia.Questionnaires were used to collect the clinical data,the compliance of taking medicine and the caring ability of their family,univariate analysis as well as Logistic multifactorial analyses were performed.Results The age,body mass index,duration of DM,medication adherence,and care giving ability between the two groups were compared,and the differences were statistically significant(all P<0.05).Logistic multifactorial analysis suggested that body mass index,age,medication adherence,duration of DM,and care giving ability were independent risk factors of the incidence of hypoglycemia in DM combined with CRF patients treated with hemodialysis(all P<0.05).Conclusion Age,body mass index,DM duration,medication adherence,and care giving ability are all risk fac-tors of the incidence of hypoglycemia in DM combined with CRF patients treated with hemodialysis.