Objective To study the effect of degu insulin combined with liraglutide in the treatment of refractory type 2 diabetes mellitus.Methods A total of eighty patients with refractory type 2 diabetes admitted to Beijing Sixth Hospi-tal from July 2022 to July 2023 were selected as the study objects and divided into study group and control group by random number table method,with forty cases in each group.The control group was given the combination of insulin glargine and insulin aspartate,and the study group was given the combination of degu insulin and liraglutide.The therapeutic effect of two groups was analyzed.Results After treatment,the glycosylated hemoglobin index of the study group was(7.18±1.11)%,the fasting blood glucose index was(6.18±0.13)mmol/L,and the blood glucose index of 2 hours after meals was(7.35±1.15)mmol/L,which were better than(8.28±1.01)%,(6.93±0.22)mmol/L,(8.02±1.58)mmol/L of the control group,and the differences were statistically significant(t=4.636,18.562,2.168,all P<0.05).Af-ter treatment,islet function in the study group was better than that in the control group,and the difference was statisti-cally significant(P<0.05).The total incidence of adverse reactions in the study group was lower than that in the con-trol group,and the difference was statistically significant(P<0.05).Conclusion The treatment of refractory type 2 dia-betes mellitus with deglu insulin and liraglutide can improve the islet function and blood glucose index of patients,and it is safe.
Degu insulinLiraglutideRefractory type 2 diabetes mellitusBlood glucose index
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