二甲双胍和阿卡波糖对早期糖尿病的疗效研究
Efficacy of Metformin and Acarbose in Early Diabetes Mellitus
任娜 1王强 1王琛2
作者信息
- 1. 济南市人民政府机关门诊部药剂科,山东济南 250099
- 2. 济南市人民政府机关门诊部检验科,山东济南 250099
- 折叠
摘要
目的 评价对早期糖尿病患者给予二甲双胍、阿卡波糖治疗的有效性.方法 回顾性选取2023年1-10月济南市人民政府机关门诊部80例糖尿病患者的临床资料,依据平衡序贯法分为两组.对照组38例,给予二甲双胍常规治疗;观察组42例,在二甲双胍基础上联合使用阿卡波糖治疗.比较两组临床疗效、糖脂代谢指标、不良反应总发生率.结果 观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05).治疗后,观察组各项糖脂代谢指标水平均优于对照组,差异有统计学意义(P均<0.05).两组不良反应总发生率比较,差异无统计学意义(P>0.05).结论 在二甲双胍基础上联合使用阿卡波糖治疗糖尿病有显著效果,可在提升治疗有效率的基础上强化用药安全性.
Abstract
Objective To evaluate the efficacy of metformin and acarbose in early diabetic patients.Methods The clinical data of 80 patients with diabetes in Jinan People's Government Office Qutpatient Department from January to October 2023 were retrospectively selected and divided into two groups according to the balanced sequential method.The control group(38 cases)received conventional treatment with metformin,and the observation group(42 cases)re-ceived acarbose combined with metformin.The clinical efficacy,glucose and lipid metabolism indexes and the total in-cidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of glucose and lipid metabolism indexes in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).There was no statistically sig-nificant difference in total incidence of adverse reactions between the two groups(P>0.05).Conclusion Combined use of acarbose on the basis of metformin in the treatment of diabetes has a significant effect,and can enhance the safety of medication on the basis of improving the treatment efficiency.
关键词
早期糖尿病/二甲双胍/阿卡波糖/疗效/血糖/脂代谢Key words
Early diabetes mellitus/Metformin/Acarbose/Curative effect/Blood glucose/Lipid metabolism引用本文复制引用
出版年
2024
NETL
NSTL
万方数据