首页|达格列净治疗2型糖尿病合并射血分数轻度下降心力衰竭患者的临床疗效

达格列净治疗2型糖尿病合并射血分数轻度下降心力衰竭患者的临床疗效

Clinical Efficacy of Dapagliflozin in the Treatment of Type 2 Diabetes Mel-litus with Mild Ejection Fraction Decrease in Patients with Heart Failure

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目的 分析达格列净治疗2型糖尿病合并射血分数轻度下降心力衰竭患者的临床疗效.方法 选取2022年10月—2023年10月邵武市立医院收治的80例2型糖尿病合并射血分数轻度下降心力衰竭患者为研究对象,以随机数表法分为两组,每组40例.对照组采取常规降糖、抗心衰治疗方案,观察组在对照组的基础上加入达格列净治疗.比较两组血糖水平、心功能指标、不良反应发生率.结果 治疗后,观察组血糖水平低于对照组,心功能指标均优于对照组,差异有统计学意义意义(P均<0.05).两组不良反应发生率对比,差异无统计学意义(P>0.05).结论 达格列净的应用,可以显著改善2型糖尿病合并射血分数轻度下降心力衰竭患者的血糖水平,且安全性高.
Objective To analyze the clinical effect of dagaglizin in the treatment of heart failure patients with type 2 diabetes mellitus and slight decrease in ejection fraction.Methods A total of 80 patients with type 2 diabetes com-bined with mild ejection fraction decline in heart failure admitted to Shaowu Municipal Hospital from October 2022 to October 2023 were selected as the study objects and divided into two groups by random number table method,with 40 cases in each group.The control group was treated with routine hypoglycemic and anti-heart failure treatment,and the observation group was treated with dagaglizin on the basis of the control group.Blood glucose level,cardiac function index and incidence of adverse reactions were compared between the two groups.Results After treatment,the blood glucose level of the observation group was lower than that of the control group,and the cardiac function indexes were better than those of the control group,and the differences were statistically significant(both P<0.05).There was no sig-nificant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of daglipzin can significantly improve the blood glucose level in patients with type 2 diabetes mellitus and slight de-crease in ejection fraction,and it is safe.

DapagliflozinType 2 diabetesLeft ventricular ejection fractionHeart failureClinical effectAdverse reaction

危娜敏、汪太斌、乔雨珊

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邵武市立医院内分泌科,福建省邵武市 354000

达格列净 2型糖尿病 左室射血分数 心力衰竭 临床疗效 不良反应

2024

糖尿病新世界
中国病理生理学会

糖尿病新世界

影响因子:0.461
ISSN:1672-4062
年,卷(期):2024.27(5)
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