西格列汀联合高流量通气对2型糖尿病合并重症呼吸衰竭老年患者血糖水平的影响
Effect of Sitagliptin Combined with High-flow Ventilation on Blood Glu-cose Level in Elderly Patients with Type 2 Diabetes Mellitus Complicated with Severe Respiratory Failure
郑美君 1黄圆缘 1陈春霞1
作者信息
- 1. 泉州市第一医院,福建泉州 362200
- 折叠
摘要
目的 探究高流量通气联合西格列汀在2型糖尿病合并重症呼吸衰竭老年患者中的应用价值.方法 选取2023年1-12月泉州市第一医院收治的96例2型糖尿病合并重症呼吸衰竭老年患者为研究对象,采用密闭信封法分为对照组(n=48)、研究组(n=48).两组均行高流量通气,对照组口服二甲双胍片,研究组结合西格列汀治疗.比较两组干预前及干预7 d后空腹血糖(Fasting Plasma Glucose,FPG)、餐后2 h血糖(2-hour Postprandial Plasma Glucose,2 hPG)水平,干预7 d后,对比两组肺功能指标,包括用力肺活量(Forced Vital Ca-pacity,FVC)、第1 s用力呼气量(Forced Expiratory Volume In One Second,FEV1)水平.结果 干预7 d后,研究组血糖水平低于对照组,差异有统计学意义(P<0.05);研究组肺功能指标水平优于对照组,差异有统计学意义(P<0.05).结论 2型糖尿病合并重症呼吸衰竭老年患者辅以高流量通气联合西格列汀治疗,可降低血糖水平,促进肺功能恢复.
Abstract
Objective To explore the application value of high-flow ventilation combined with sitagliptin in elderly pa-tients with type 2 diabetes mellitus complicated with severe respiratory failure.Methods A total of Ninety-six elderly patients with type 2 diabetes mellitus combined with severe respiratory failure admitted to Quanzhou First Hospital from January to December 2023 were selected as the study subjects,and they were divided into control group(n=48)and study group(n=48)by using sealed envelope method.Both groups received high flow ventilation,metformin tab-lets in the control group and sitagliptin in the study group.Fasting Plasma Glucose(FPG)and 2-hour Postprandial Plasma Glucose(2 hPG)levels were compared between the two groups before and after the intervention for 7 days,and the pulmonary function indexes were compared between the two groups after the intervention for 7 days,which include Forced Vital Capacity(FVC)and Forced Expiratory Volume In One Second(FEV1).Results After 7 days of interven-tion,the blood glucose level of the study group was lower than that of the control group,and the difference was statisti-cally significant(P<0.05).The level of lung function indexes in the study group was better than that in the control group,and the difference was statistically significant(P<0.05).Conclusion In elderly patients with type 2 diabetes mellitus and severe respiratory failure,high-flow ventilation combined with sitagliptin can reduce blood glucose levels and promote the recovery of lung function.
关键词
高流量通气/糖尿病/西格列汀/血糖水平/营养状态/肺功能Key words
High-flow ventilation/Diabetes mellitus/Sitagliptin/Blood glucose levels/Nutritional status/Lung func-tion引用本文复制引用
出版年
2024
NETL
NSTL
万方数据