达格列净联合甘精胰岛素在老年T2DM患者糖代谢控制中的应用效果
The Application Effect of Dapagliflozin Combined with Glargine Insulin in Carbohydrate Metabolism Control of Elderly T2DM Patients
谢立凯 1孙亚东1
作者信息
- 1. 吉林省人民医院内分泌代谢病一科,吉林长春 130012
- 折叠
摘要
目的 分析老年2型糖尿病(Type 2 Diabetes Mellitu,T2DM)患者糖代谢控制中达格列净与甘精胰岛素联合应用的效果.方法 选取2021年5月—2023年5月吉林省人民医院收治的100例老年T2DM患者为研究对象,以信封法分为观察组(n=50,行达格列净联合甘精胰岛素治疗)、比照组(n=50,行单纯甘精胰岛素治疗).观察并对比两组患者临床疗效、糖代谢控制情况及不良反应总发生率.结果 治疗3个月后,两组糖代谢水平均明显低于治疗前,且观察组空腹血糖(6.01±0.28)mmol/L、餐后2 h血糖(7.41±1.18)mmol/L、糖化血红蛋白(6.58±1.04)%均低于比照组,差异有统计学意义(t=2.171、2.595、2.077,P均<0.05).观察组临床总有效率(96.00%)高于比照组,差异有统计学意义(χ2=5.005,P<0.05).两组不良反应总发生率对比,差异无统计学意义(P>0.05).结论 老年T2DM患者糖代谢控制中,达格列净联合甘精胰岛素的应用效果显著,糖代谢水平得到明显改善的同时,临床疗效更加显著,不良反应发生风险未产生明显升高情况,说明上述两种药物联合应用,具有较高的安全性.
Abstract
Objective To analyze the effect of dapagliflozin combined with glargine insulin on carbohydrate metabo-lism control in elderly patients with type 2 diabetes mellitus(T2DM).Methods 100 elderly T2DM patients admitted to Jilin Provincial People's Hospital from May 2021 to May 2023 were selected as the study objects.They were divided into observation group(n=50,treated with dapagliflozin combined with glargine insulin)and comparison group(n=50,treated with simple glargine insulin)using the envelope method.The clinical efficacy,carbohydrate metabolism con-trol,and total incidence of adverse reactions between two groups of patients were observed and compared.Results Af-ter 3 months of treatment,the carbohydrate metabolism level in two groups was significantly lower than before treat-ment,and the fasting blood glucose(6.01±0.28)mmol/L,2-hour postprandial blood glucose(7.41±1.18)mmol/L,and glycated hemoglobin(6.58±1.04)%in the observation group were lower than those in the comparison group,and the differences were statistically significant(t=2.171,2.595,2.077,all P<0.05).The total clinical effective rate of the ob-servation group(96.00%)was higher than that of the comparison group,and the difference was statistically significant(χ2=5.005,P<0.05).There was no statistically significant difference in the total incidence of adverse reactions be-tween the two groups(P>0.05).Conclusion In the control of carbohydrate metabolism of elderly T2DM patients,the application of dapagliflozin and glargine insulin was effective,and while the level of carbohydrate metabolism was sig-nificantly improved,the clinical efficacy was more significant,and the risk of adverse reactions did not produce a sig-nificant elevation of the situation,indicating that the combined application of the above two drugs has a high degree of safety.
关键词
老年T2DM患者/达格列净/甘精胰岛素/糖代谢/临床疗效/不良反应Key words
Elderly T2DM patients/Dapagliflozin/Glargine insulin/Carbohydrate metabolism/Clinical efficacy/Ad-verse reactions引用本文复制引用
出版年
2024
NETL
NSTL
万方数据