Objective To study the effect of humanized nursing model applied to diabetic patients in perioperative pe-riod.Methods A total of 60 diabetes patients of perioperative period treated in Honghu Hospital of Traditional Chi-nese Medicine from January 2022 to May 2023 were selected as the study objects.They were divided into observation group(n=30)and control group(n=30)by sealed envelope method,and the control group received routine nursing,and the study group received humanized nursing.The psychological state and comfort level of nursing were observed and compared between groups before and after nursing.Results After giving humanized nursing,the scores of self-rating depression scale(SDS)and self-rating anxiety scale(SAS)in the study group were lower than those in the control group,and the differences were statistically significant(both P<0.05).The comfort of nursing in the study group(96.67%)was higher than that in the control group(76.67%),and the difference was statistically significant(P<0.05).Conclusion Applying humanized nursing to diabetic patients during perioperative period can obtain ideal effect,which has positive influence on improving patients'psychological state and comfort level,and has popularization sig-nificance.